携带 rplD 基因突变的猪梭状芽孢杆菌对利奈唑胺的耐药性。rplD 基因编码核糖体蛋白 L4。
Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4.
机构信息
Chair of Animal Hygiene, Technische Universität München, Weihenstephaner Berg 3, 85354 Freising, Germany.
出版信息
Antimicrob Agents Chemother. 2010 Mar;54(3):1351-3. doi: 10.1128/AAC.01208-09. Epub 2010 Jan 11.
Abstract
Coresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. A Clostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new mutation in a highly conserved region of rplD, encoding protein L4 of the 50S ribosomal subunit. This is the first genetic substantiation of linezolid resistance in the genus Clostridium.
摘要
兽用抗生素的使用可能导致人类储备抗生素产生耐药性。从猪粪中分离出的产气荚膜梭菌对储备药物利奈唑胺具有耐药性，同时对氟苯尼考和红霉素也具有耐药性。我们在编码 50S 核糖体亚基蛋白 L4 的 rplD 高度保守区域检测到一个新的突变。这是首次在梭菌属中发现利奈唑胺耐药的遗传证据。
相似文献
1
Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4.
Antimicrob Agents Chemother. 2010 Mar;54(3):1351-3. doi: 10.1128/AAC.01208-09. Epub 2010 Jan 11.
2
Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3.
Antimicrob Agents Chemother. 2010 Dec;54(12):5352-5. doi: 10.1128/AAC.00714-10. Epub 2010 Sep 13.
3
Clinical and microbiological aspects of linezolid resistance mediated by the cfr gene encoding a 23S rRNA methyltransferase.
J Clin Microbiol. 2008 Mar;46(3):892-6. doi: 10.1128/JCM.01886-07. Epub 2008 Jan 3.
4
Introduction of erm(C) into a linezolid- and methicillin-resistant Staphylococcus aureus does not restore linezolid susceptibility.
J Antimicrob Chemother. 2003 Apr;51(4):1039-41. doi: 10.1093/jac/dkg194.
5
Detection of oxazolidinone and phenicol resistant enterococcal isolates from duck feces and carcasses.
Int J Food Microbiol. 2019 Mar 16;293:53-59. doi: 10.1016/j.ijfoodmicro.2019.01.002. Epub 2019 Jan 6.
6
Detection of linezolid-resistant Staphylococcus aureus with 23S rRNA and novel L4 riboprotein mutations in a cystic fibrosis patient in Spain.
Antimicrob Agents Chemother. 2013 May;57(5):2428-9. doi: 10.1128/AAC.00208-13. Epub 2013 Mar 4.
7
Different Resistance Mechanisms for Cadazolid and Linezolid in Clostridium difficile Found by Whole-Genome Sequencing Analysis.
Antimicrob Agents Chemother. 2017 Jul 25;61(8). doi: 10.1128/AAC.00384-17. Print 2017 Aug.
8
Linezolid-resistant Enterococcus faecalis isolated from a cord blood transplant recipient.
J Clin Microbiol. 2004 Apr;42(4):1843-5. doi: 10.1128/JCM.42.4.1843-1845.2004.
9
First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States.
Antimicrob Agents Chemother. 2008 Jun;52(6):2244-6. doi: 10.1128/AAC.00231-08. Epub 2008 Apr 7.
10
Linezolid-resistant clinical isolates of enterococci and Staphylococcus cohnii from a multicentre study in China: molecular epidemiology and resistance mechanisms.
Int J Antimicrob Agents. 2013 Oct;42(4):317-21. doi: 10.1016/j.ijantimicag.2013.06.008. Epub 2013 Jul 20.
引用本文的文献
1
Mechanisms of linezolid resistance in Staphylococcus capitis with the novel mutation C2128T in the 23S rRNA gene in China.
BMC Microbiol. 2022 Aug 20;22(1):203. doi: 10.1186/s12866-022-02616-9.
2
A study on fungal defensin against multidrug-resistant Clostridium perfringens and its treatment on infected poultry.
Appl Microbiol Biotechnol. 2021 Oct;105(19):7265-7282. doi: 10.1007/s00253-021-11500-x. Epub 2021 Sep 7.
3
Mobile Oxazolidinone Resistance Genes in Gram-Positive and Gram-Negative Bacteria.
Clin Microbiol Rev. 2021 Jun 16;34(3):e0018820. doi: 10.1128/CMR.00188-20. Epub 2021 Jun 2.
4
Identification of Antimicrobial Resistance-Associated Genes through Whole Genome Sequencing of Isolates with Different Antimicrobial Resistances.
Pathogens. 2020 Jul 19;9(7):588. doi: 10.3390/pathogens9070588.
5
Antimicrobial Resistance in and spp. and Other Anaerobes.
Microbiol Spectr. 2020 Jan;8(1). doi: 10.1128/microbiolspec.ARBA-0020-2017.
6
Determination of multidrug resistance mechanisms in Clostridium perfringens type A isolates using RNA sequencing and 2D-electrophoresis.
Braz J Med Biol Res. 2018 Jun 11;51(8):e7044. doi: 10.1590/1414-431X20187044.
7
Whole genome sequencing analyses of Listeria monocytogenes that persisted in a milkshake machine for a year and caused illnesses in Washington State.
BMC Microbiol. 2017 Jun 15;17(1):134. doi: 10.1186/s12866-017-1043-1.
8
Different Resistance Mechanisms for Cadazolid and Linezolid in Clostridium difficile Found by Whole-Genome Sequencing Analysis.
Antimicrob Agents Chemother. 2017 Jul 25;61(8). doi: 10.1128/AAC.00384-17. Print 2017 Aug.
9
Antibiotic Sensitivity of Clostridium perfringens Isolated From Faeces in Tabriz, Iran.
Jundishapur J Microbiol. 2015 Jul 25;8(7):e20863. doi: 10.5812/jjm.20863v2. eCollection 2015 Jul.
10
Clonal dissemination of linezolid-resistant Staphylococcus capitis with G2603T mutation in domain V of the 23S rRNA and the cfr gene at a tertiary care hospital in China.
BMC Infect Dis. 2015 Feb 26;15:97. doi: 10.1186/s12879-015-0841-z.
本文引用的文献
1
Phenotypic and genotypic bacterial antimicrobial resistance in liquid pig manure is variously associated with contents of tetracyclines and sulfonamides.
J Appl Microbiol. 2010 May;108(5):1642-56. doi: 10.1111/j.1365-2672.2009.04570.x. Epub 2009 Sep 29.
2
Antimicrobial resistance in Clostridium perfringens isolates from broilers in Belgium.
Vet Res Commun. 2009 Dec;33(8):1031-7. doi: 10.1007/s11259-009-9306-4.
3
Clostridium perfringens sporulation and its relevance to pathogenesis.
Future Microbiol. 2009 Jun;4(5):519-25. doi: 10.2217/fmb.09.31.
4
Comparative analysis on antibiotic resistance characteristics of Listeria spp. and Enterococcus spp. isolated from laying hens and eggs in conventional and organic keeping systems in Bavaria, Germany.
Zoonoses Public Health. 2010 May;57(3):171-80. doi: 10.1111/j.1863-2378.2008.01229.x.
5
Diversity and susceptibility of Enterococcus isolated from cattle before and after harvest.
J Food Prot. 2009 Apr;72(4):766-74. doi: 10.4315/0362-028x-72.4.766.
6
Epidemiology and outcomes of clostridial bacteremia at a tertiary-care institution.
ScientificWorldJournal. 2009 Feb 28;9:144-8. doi: 10.1100/tsw.2009.21.
7
Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr.
Antimicrob Agents Chemother. 2009 Feb;53(2):779-81. doi: 10.1128/AAC.01376-08. Epub 2008 Dec 1.
8
Characterization of antimicrobial resistance of foodborne Listeria monocytogenes.
Int J Food Microbiol. 2009 Jan 15;128(3):497-500. doi: 10.1016/j.ijfoodmicro.2008.10.018. Epub 2008 Oct 28.
9
Salmonella spp. in Bavarian liquid pig manure: occurrence and relevance for the distribution of antibiotic resistance.
Zoonoses Public Health. 2008 Apr;55(3):133-8. doi: 10.1111/j.1863-2378.2007.01102.x.
10
Outcome of brain abscess by Clostridium perfringens.
Neurosurgery. 2007 Dec;61(6):E1339; discussion E1339. doi: 10.1227/01.neu.0000306118.31410.75.
Zotero 插件