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1
Phenotypic and genotypic bacterial antimicrobial resistance in liquid pig manure is variously associated with contents of tetracyclines and sulfonamides.液态猪粪中的细菌表型和基因型抗菌耐药性与四环素和磺胺类药物的含量呈不同程度相关。
J Appl Microbiol. 2010 May;108(5):1642-56. doi: 10.1111/j.1365-2672.2009.04570.x. Epub 2009 Sep 29.
2
Antimicrobial resistance in Clostridium perfringens isolates from broilers in Belgium.从比利时肉鸡中分离的产气荚膜梭菌的抗微生物耐药性。
Vet Res Commun. 2009 Dec;33(8):1031-7. doi: 10.1007/s11259-009-9306-4.
3
Clostridium perfringens sporulation and its relevance to pathogenesis.产气荚膜梭菌的芽孢形成及其与发病机制的相关性。
Future Microbiol. 2009 Jun;4(5):519-25. doi: 10.2217/fmb.09.31.
4
Comparative analysis on antibiotic resistance characteristics of Listeria spp. and Enterococcus spp. isolated from laying hens and eggs in conventional and organic keeping systems in Bavaria, Germany.德国巴伐利亚州常规和有机饲养系统中产蛋鸡和鸡蛋中分离的李斯特菌和肠球菌的抗生素耐药特性比较分析。
Zoonoses Public Health. 2010 May;57(3):171-80. doi: 10.1111/j.1863-2378.2008.01229.x.
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Diversity and susceptibility of Enterococcus isolated from cattle before and after harvest.
J Food Prot. 2009 Apr;72(4):766-74. doi: 10.4315/0362-028x-72.4.766.
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Epidemiology and outcomes of clostridial bacteremia at a tertiary-care institution.一家三级医疗机构中梭菌血症的流行病学及转归
ScientificWorldJournal. 2009 Feb 28;9:144-8. doi: 10.1100/tsw.2009.21.
7
Methicillin-resistant and -susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr.来自猪的克隆谱系ST398和ST9的耐甲氧西林和甲氧西林敏感金黄色葡萄球菌菌株携带多药耐药基因cfr。
Antimicrob Agents Chemother. 2009 Feb;53(2):779-81. doi: 10.1128/AAC.01376-08. Epub 2008 Dec 1.
8
Characterization of antimicrobial resistance of foodborne Listeria monocytogenes.食源性单核细胞增生李斯特菌的抗菌药物耐药性特征分析
Int J Food Microbiol. 2009 Jan 15;128(3):497-500. doi: 10.1016/j.ijfoodmicro.2008.10.018. Epub 2008 Oct 28.
9
Salmonella spp. in Bavarian liquid pig manure: occurrence and relevance for the distribution of antibiotic resistance.巴伐利亚液态猪粪中的沙门氏菌属：抗生素耐药性分布的现状及相关性
Zoonoses Public Health. 2008 Apr;55(3):133-8. doi: 10.1111/j.1863-2378.2007.01102.x.
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Outcome of brain abscess by Clostridium perfringens.产气荚膜梭菌所致脑脓肿的结局
Neurosurgery. 2007 Dec;61(6):E1339; discussion E1339. doi: 10.1227/01.neu.0000306118.31410.75.

携带 rplD 基因突变的猪梭状芽孢杆菌对利奈唑胺的耐药性。rplD 基因编码核糖体蛋白 L4。

Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4.

机构信息

Chair of Animal Hygiene, Technische Universität München, Weihenstephaner Berg 3, 85354 Freising, Germany.

出版信息

Antimicrob Agents Chemother. 2010 Mar;54(3):1351-3. doi: 10.1128/AAC.01208-09. Epub 2010 Jan 11.

DOI:10.1128/AAC.01208-09
PMID:20065060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2825973/
Abstract

Coresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. A Clostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new mutation in a highly conserved region of rplD, encoding protein L4 of the 50S ribosomal subunit. This is the first genetic substantiation of linezolid resistance in the genus Clostridium.

摘要

兽用抗生素的使用可能导致人类储备抗生素产生耐药性。从猪粪中分离出的产气荚膜梭菌对储备药物利奈唑胺具有耐药性，同时对氟苯尼考和红霉素也具有耐药性。我们在编码 50S 核糖体亚基蛋白 L4 的 rplD 高度保守区域检测到一个新的突变。这是首次在梭菌属中发现利奈唑胺耐药的遗传证据。