ORAOV1-A与口腔癌的低分化相关。
ORAOV1-A correlates with poor differentiation in oral cancer.
作者信息
Jiang L, Yang H S, Wang Z, Zhou Y, Zhou M, Zeng X, Chen Q M
机构信息
State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No. 14, Sec.3, Renminnan Road, Chengdu, Sichuan, 610041, China.
出版信息
J Dent Res. 2009 May;88(5):433-8. doi: 10.1177/0022034509336994.
Oral cancer overexpressed 1 (ORAOV1) is a crucial oncogene in oral squamous cell carcinoma (OSCC). In this study, we have identified a novel splice variant of ORAOV1, designated as ORAOV1-A. To study the potential role of ORAOV1-A in OSCC, we tested its expression in 7 OSCC cell lines, as well as in 19 normal oral tissue samples and 47 OSCC tissue samples. The expression of ORAOV1-A was detectable in 6 out of 7 OSCC cell lines tested. In OSCC tissue samples, the expression frequency of ORAOV1-A (51.1%) was much higher than that in normal samples (10.5%). Notably, an inverse correlation was found between the expression frequency of ORAOV1-A and the degree of differentiation in OSCC (P = 0.0017). In conclusion, our results suggested that ORAOV1-A may play a functional role in the tumorigenesis of OSCC, and ORAOV1-A expression may serve as an adjunctive prognostic indicator for persons with OSCC.
口腔癌过表达1（ORAOV1）是口腔鳞状细胞癌（OSCC）中的一种关键癌基因。在本研究中，我们鉴定出ORAOV1的一种新型剪接变体，命名为ORAOV1-A。为了研究ORAOV1-A在OSCC中的潜在作用，我们检测了其在7种OSCC细胞系以及19个正常口腔组织样本和47个OSCC组织样本中的表达情况。在所检测的7种OSCC细胞系中，有6种可检测到ORAOV1-A的表达。在OSCC组织样本中，ORAOV1-A的表达频率（51.1%）远高于正常样本（10.5%）。值得注意的是，在OSCC中发现ORAOV1-A的表达频率与分化程度呈负相关（P = 0.0017）。总之，我们的结果表明ORAOV1-A可能在OSCC的肿瘤发生中发挥功能性作用，且ORAOV1-A的表达可能作为OSCC患者的辅助预后指标。
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