Wu Kehan, Sun Qianhui, Liu Dongxu, Lu Jiayi, Wen Deyu, Zang Xiyan, Gao Li
Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, PR China.
Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, PR China.
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241272051. doi: 10.1177/15330338241272051.
Head and neck malignancies are a significant global health concern, with head and neck squamous cell carcinoma (HNSCC) being the sixth most common cancer worldwide accounting for > 90% of cases. In recent years, there has been growing recognition of the potential role of alternative splicing (AS) in the etiology of cancer. Increasing evidence suggests that AS is associated with various aspects of cancer progression, including tumor occurrence, invasion, metastasis, and drug resistance. Additionally, AS is involved in shaping the tumor microenvironment, which plays a crucial role in tumor development and response to therapy. AS can influence the expression of factors involved in angiogenesis, immune response, and extracellular matrix remodeling, all of which contribute to the formation of a supportive microenvironment for tumor growth. Exploring the mechanism of AS events in HNSCC could provide insights into the development and progression of this cancer, as well as its interaction with the tumor microenvironment. Understanding how AS contributes to the molecular changes in HNSCC cells and influences the tumor microenvironment could lead to the identification of new therapeutic targets. Targeted chemotherapy and immunotherapy strategies tailored to the specific AS patterns in HNSCC could potentially improve treatment outcomes and reduce side effects. This review explores the concept, types, processes, and technological advancements of AS, focusing on its role in the initiation, progression, treatment, and prognosis of HNSCC.
头颈部恶性肿瘤是全球重大的健康问题，头颈部鳞状细胞癌（HNSCC）是全球第六大常见癌症，占病例的90%以上。近年来，人们越来越认识到可变剪接（AS）在癌症病因学中的潜在作用。越来越多的证据表明，AS与癌症进展的各个方面相关，包括肿瘤发生、侵袭、转移和耐药性。此外，AS参与塑造肿瘤微环境，而肿瘤微环境在肿瘤发展和对治疗的反应中起着至关重要的作用。AS可以影响参与血管生成、免疫反应和细胞外基质重塑的因子的表达，所有这些都有助于形成支持肿瘤生长的微环境。探索HNSCC中AS事件的机制可以为这种癌症的发展和进展及其与肿瘤微环境的相互作用提供见解。了解AS如何促成HNSCC细胞的分子变化并影响肿瘤微环境可能会导致确定新的治疗靶点。针对HNSCC中特定AS模式的靶向化疗和免疫治疗策略可能会改善治疗效果并减少副作用。本综述探讨了AS的概念、类型、过程和技术进展，重点关注其在HNSCC的起始、进展、治疗和预后中的作用。
