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[同种异体输尿管替代及其临床应用的局限性。现状分析]

[Alloplastic ureter substitution and limitations in clinical application. A status analysis].

作者信息

Becht E, Derouet H, Ziegler M

机构信息

Urologische Universitätsklinik und Poliklinik, Universität des Saarlandes, Homburg/Saar.

出版信息

Urologe A. 1991 Sep;30(5):299-301.

PMID:1949437
Abstract

Operative ureteral replacement with the patient's own body tissue or by reconstructive ureteral surgery is indicated relatively often. The operative methods applied vary: they include pelvic flap pyeloplasty, caudal transposition of the kidney, interposition of the small intestine, trans-ureterostomy, calico-ureterostomy, of bladder flap transplantation and autotransplantation of the kidney. When the indications are correctly observed with reference to the kind and location of the ureteral lesion all these methods are successful. The methods of alloplastic replacement of the ureter, in contrast, have lost clinical importance and should be performed only in rare, isolated cases, mainly as a short-term solution. Possible indications are a poor general condition in patients for whom alloplastic ureteral replacement is the only alternative to permanent nephrostomy and malignant tumours requiring immediate irradiation, which cannot be postponed until definitive wound healing has taken place following a plastic operation. It is important that problems of biocompatibility have now been largely overcome. Segmental ureteral replacement with alloplastic materials is not possible, however, and the functional difficulties with urinary transport have not been solved in the long term, even in models with pumps and reflux-preventing mechanisms.

摘要

使用患者自身身体组织或通过输尿管重建手术进行手术性输尿管替代相对较为常见。所应用的手术方法各不相同:包括盆腔皮瓣肾盂成形术、肾脏尾侧移位术、小肠间置术、输尿管造口术、肾盂输尿管造口术、膀胱皮瓣移植术和肾脏自体移植术。当根据输尿管病变的类型和位置正确遵循适应证时,所有这些方法都是成功的。相比之下,输尿管异体替代方法已失去临床重要性,仅应在罕见的孤立病例中进行,主要作为短期解决方案。可能的适应证包括一般状况较差的患者,对于他们来说,异体输尿管替代是永久性肾造瘘的唯一替代方法,以及需要立即进行放疗的恶性肿瘤,而这不能推迟到整形手术后伤口完全愈合。重要的是,生物相容性问题现在已基本得到克服。然而,使用异体材料进行节段性输尿管替代是不可能的,而且即使在具有泵和防反流机制的模型中,尿液输送的功能困难也无法长期解决。

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