Sze Henry, Yeung M W
Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong.
Hong Kong Med J. 2009 Jun;15(3):221-3.
Fibromatosis is a rare disease with benign histology. Its infiltrative growth pattern may prevent complete resection. We report a case of a 40-year-old woman with fibromatosis of the neck requiring an emergency operation for acute upper airway obstruction. Gross residual tumour was left behind but excellent tumour shrinkage was achieved by using weekly low-dose methotrexate and vinblastine. Despite the use of newer agents such as imatinib, cytotoxic chemotherapy remains an efficacious treatment for inoperable fibromatosis.
纤维瘤病是一种组织学表现为良性的罕见疾病。其浸润性生长方式可能导致无法完全切除。我们报告一例40岁颈部纤维瘤病女性患者，因急性上呼吸道梗阻需紧急手术。术后残留肉眼可见的肿瘤，但通过每周使用低剂量甲氨蝶呤和长春碱，肿瘤实现了显著缩小。尽管使用了伊马替尼等新型药物，但细胞毒性化疗仍是无法手术切除的纤维瘤病的有效治疗方法。
