Lee K J, Cha D Y, Cheon S J, Yeo M, Cho S W
Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea.
Digestion. 2009;80(1):58-63. doi: 10.1159/000215389. Epub 2009 Jun 3.
BACKGROUND/AIMS: Ghrelin affects gastric motility. However, little is known about the role of ghrelin in the pathophysiology of functional dyspepsia (FD). We investigated plasma ghrelin levels and their relationship with gastric emptying time in dysmotility-like FD patients.
42 patients with dysmotility-like FD and 14 healthy volunteers were enrolled in the study. Gastric half-emptying time was measured using a radiolabeled meal. Plasma total ghrelin levels before and after the meal were determined using a radioimmunoassay kit.
Preprandial ghrelin levels were significantly lower in FD patients than in controls. Postprandial ghrelin levels were similar between the two groups. Abnormally low preprandial ghrelin levels were observed in 7 out of 42 patients, in whom significant postprandial decrease of ghrelin levels was absent. Delayed gastric emptying was observed in 5 out of 7 patients with abnormally low ghrelin levels. Pre- or postprandial ghrelin levels were not significantly correlated with gastric half-emptying time, both in the patient group and in the control group.
Abnormally low preprandial ghrelin levels and absence of significant postprandial decrease of ghrelin levels are present in a subset of dysmotility-like FD patients. Further investigation on the pathogenetic implication of these alterations in FD is required.
背景/目的：胃饥饿素影响胃动力。然而，胃饥饿素在功能性消化不良（FD）病理生理学中的作用尚不清楚。我们研究了动力障碍样FD患者的血浆胃饥饿素水平及其与胃排空时间的关系。
42例动力障碍样FD患者和14名健康志愿者纳入本研究。使用放射性标记餐测量胃半排空时间。使用放射免疫分析试剂盒测定餐前和餐后血浆总胃饥饿素水平。
FD患者的餐前胃饥饿素水平显著低于对照组。两组餐后胃饥饿素水平相似。42例患者中有7例观察到餐前胃饥饿素水平异常低，其中餐后胃饥饿素水平无显著下降。7例胃饥饿素水平异常低的患者中有5例观察到胃排空延迟。在患者组和对照组中，餐前或餐后胃饥饿素水平与胃半排空时间均无显著相关性。
一部分动力障碍样FD患者存在餐前胃饥饿素水平异常低以及餐后胃饥饿素水平无显著下降的情况。需要进一步研究这些改变在FD发病机制中的意义。
