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采用主动稳定自适应光学光学相干断层扫描技术的视网膜电图检查。

Optoretinography with actively stabilized adaptive optics optical coherence tomography.

作者信息

Wong Jason H, Luo Shangbang, Hosseinaee Zohreh, Feroldi Fabio, Roorda Austin

机构信息

Herbert Wertheim School of Optometry and Vision Science, University of California Berkeley, Berkeley, CA 94720-2020, USA.

出版信息

Biomed Opt Express. 2025 Jul 17;16(8):3222-3236. doi: 10.1364/BOE.566376. eCollection 2025 Aug 1.

DOI:10.1364/BOE.566376
PMID:40809971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12339298/
Abstract

Optoretinography (ORG) is the optical measurement of changes in the retina in response to light stimulation. Adaptive optics optical coherence tomography (AOOCT) records photoreceptor ORGs by measuring the physical changes in their outer segment lengths in response to light stimulation. The main difficulty in recording these nanometer-scale changes is constant eye motion. Typically, fast volume acquisitions are used with offline spatial registration to compensate for the effect of eye motion. Here, we present an alternate solution whereby an adaptive optics scanning light ophthalmoscope (AOSLO) is used to measure the eye motion and actively guide the AOOCT beam to compensate for eye motion in real time. This system's cellular-scale tracking offers unparalleled control over scanning raster size and shape, allowing for high-speed (up to 100 kHz) ORG acquisition from targeted locations. We validate the method by comparing cone classifications against those made with an established ORG approach.

摘要

视网膜光响应成像（ORG）是对视网膜因光刺激而产生的变化进行光学测量。自适应光学光学相干断层扫描（AOOCT）通过测量光感受器外段长度因光刺激而产生的物理变化来记录光感受器ORG。记录这些纳米级变化的主要困难在于眼睛的持续运动。通常，使用快速体积采集结合离线空间配准来补偿眼睛运动的影响。在此，我们提出一种替代解决方案，即使用自适应光学扫描激光检眼镜（AOSLO）来测量眼睛运动，并实时主动引导AOOCT光束以补偿眼睛运动。该系统的细胞尺度跟踪对扫描光栅的大小和形状提供了无与伦比的控制，允许从目标位置进行高速（高达100 kHz）的ORG采集。我们通过将视锥细胞分类与使用既定ORG方法进行的分类相比较来验证该方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/8a04e66a60d5/boe-16-8-3222-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/92518c4caa72/boe-16-8-3222-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/539e93424619/boe-16-8-3222-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/55c391c270b2/boe-16-8-3222-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/d6d2ac38847a/boe-16-8-3222-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/b315a6519d58/boe-16-8-3222-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/c8dd1c21b8eb/boe-16-8-3222-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/8a04e66a60d5/boe-16-8-3222-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/92518c4caa72/boe-16-8-3222-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/539e93424619/boe-16-8-3222-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/55c391c270b2/boe-16-8-3222-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/d6d2ac38847a/boe-16-8-3222-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/b315a6519d58/boe-16-8-3222-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/c8dd1c21b8eb/boe-16-8-3222-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608c/12339298/8a04e66a60d5/boe-16-8-3222-g007.jpg

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本文引用的文献

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J Phys D Appl Phys. 2025 Apr 7;58(14):145102. doi: 10.1088/1361-6463/adb3b4. Epub 2025 Feb 21.
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Unique yellow shifts for small and brief stimuli in the central retina.中央视网膜中对小而短暂刺激的独特黄色位移。
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Evolution of adaptive optics retinal imaging [Invited].自适应光学视网膜成像的发展[特邀报告]
Biomed Opt Express. 2023 Feb 28;14(3):1307-1338. doi: 10.1364/BOE.485371. eCollection 2023 Mar 1.
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Coarse-scale optoretinography (CoORG) with extended field-of-view for normative characterization.用于规范表征的具有扩展视野的粗尺度视网膜电图(CoORG)。
Biomed Opt Express. 2022 Oct 24;13(11):5989-6002. doi: 10.1364/BOE.473475. eCollection 2022 Nov 1.
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Retinal imaging using adaptive optics optical coherence tomography with fast and accurate real-time tracking.使用自适应光学光学相干断层扫描并具备快速准确实时跟踪功能的视网膜成像。
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