Bly J E, Clem L W
Department of Microbiology, University of Mississippi Medical Center, Jackson 39216-4505.
Vet Immunol Immunopathol. 1991 Jul;28(3-4):365-77. doi: 10.1016/0165-2427(91)90127-x.
In an attempt to understand the interrelationships between environmental temperature and immune competence, channel catfish in the laboratory were subjected to a rapid change in water temperature in order to mimic conditions which might be encountered in commercial ponds during the winter months and subsequently examined for a variety of immune parameters. The results indicated that lowering the water temperature from 23 to 11 degrees C over a 24 h period suppressed both B and T cell functions for 3-5 weeks as assessed by in vitro responses. Furthermore, this form of suppression was not a typical stress-induced response, i.e. blood serum chemistry and lymphocyte and neutrophil compositions did not change in a manner reminiscent of transport-induced stress. Collectively these results indicate that channel catfish are probably immunocompromised during the winter months and consequently it seems plausible that many of the fish losses associated with the syndrome termed "winter kill" may be attributable, at least in part, to a low temperature-induced immuno-deficient state.
为了了解环境温度与免疫能力之间的相互关系，实验室中的斑点叉尾鮰经历了水温的快速变化，以模拟冬季商业池塘可能遇到的情况，随后检测了各种免疫参数。结果表明，在24小时内将水温从23摄氏度降至11摄氏度，通过体外反应评估，B细胞和T细胞功能均被抑制3至5周。此外，这种抑制形式并非典型的应激诱导反应，即血清化学以及淋巴细胞和中性粒细胞组成并未以类似于运输诱导应激的方式发生变化。这些结果共同表明，斑点叉尾鮰在冬季可能免疫功能受损，因此，许多与“冬季死亡”综合征相关的鱼类损失似乎至少部分可归因于低温诱导的免疫缺陷状态。
