瓦勒氏综合征：硬皮病鉴别诊断中较为罕见的疾病。

Werner's syndrome: a quite rare disease for differential diagnosis of scleroderma.

机构信息

Internal Medicine, Rheumatology Department, Izzet Baysal Medical Faculty, Abant Izzet Baysal University, Gölköy, Bolu, Turkey.

出版信息

Rheumatol Int. 2010 Mar;30(5):695-8. doi: 10.1007/s00296-009-0982-8. Epub 2009 Jun 3.

DOI:10.1007/s00296-009-0982-8

PMID:19495768

Abstract

Werner's syndrome (WS) is an autosomal recessive disorder characterized by premature aging. The main features of the disease are scleroderma-like skin appearance, premature atherosclerosis, short stature, diabetes mellitus, early osteoporosis and early aging. Herein, we describe a patient with WS, who has scleroderma-like skin changes and discuss the literature about WS as a disease in the differential diagnosis of systemic sclerosis.

摘要

Werner 综合征（WS）是一种常染色体隐性遗传病，其特征为早衰。该病的主要特征为硬皮病样皮肤表现、早发动脉粥样硬化、身材矮小、糖尿病、早发性骨质疏松症和早老。本文报道了 1 例 WS 患者，其具有硬皮病样皮肤改变，并就 WS 作为系统性硬化症鉴别诊断中的一种疾病的文献进行了讨论。