A typical patient with this uncommon premature aging syndrome was followed over a period of four and a half years until his death. He presented the characteristic clinical features, as well as the complications, of Werner's syndrome. About one hundred forty cases of this recessively inherited syndrome have been reported. Most patients become recognizable in their thirties by their short stature, typical facies, premature graying, hair loss, cataracts, atrophy of skin and subcutaneous tissue, and acral sclerosis. Advanced peripheral vascular disease occurs early; angina, skin cancer, diabetes mellitus, and internal malignancy are common. Most patients die before the age of fifty years either from complications of anteriosclerotic vascular disease or malignancy.
一名患有这种罕见早衰综合征的典型患者被跟踪观察了四年半，直至其死亡。他表现出了沃纳综合征的典型临床特征及并发症。这种隐性遗传综合征已报告了约140例。大多数患者在三十多岁时因身材矮小、典型面容、过早白发、脱发、白内障、皮肤和皮下组织萎缩以及肢端硬化而被识别出来。晚期外周血管疾病出现较早；心绞痛、皮肤癌、糖尿病和内脏恶性肿瘤很常见。大多数患者在五十岁之前死于动脉硬化性血管疾病并发症或恶性肿瘤。
