Watanabe Kouichi, Okawa Seigo, Kanatani Mitugu, Homma Kikuo
Division of Biomaterial Science, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, 5274 Gakkoucho-dori 2, Chuo-ku, Niigata 951-8514, Japan.
Dent Mater J. 2009 Mar;28(2):178-84. doi: 10.4012/dmj.28.178.
To gain insight on the early biological response to commercial pure titanium (cpTi), the surface properties of cpTi implants retrieved from rat bone were examined by X-ray photoelectron spectroscopy (XPS). To this end, semi-cylindrical bullets, 1.1 mm in diameter and 3.5 mm in length, were implanted into the femurs of Wistar rats and then retrieved after either 3 hours or 7 days. Regardless of implantation interval, elements of Ti, O, C, and N were observed on the retrieved implants and that the thickness of the adsorbed film (mainly protein) was estimated to be about 2.5 nm. Small amounts of both Ca and P were also detected, whereby the Ca/P atomic ratios after 3 hours and 7 days were very small compared to that of hydroxyapatite. Furthermore, no correlation was found between the Ca and P distributions in the element maps. In conclusion, no calcium phosphate compounds were formed on the implant in vivo after 7 days.
为深入了解对商业纯钛（cpTi）的早期生物学反应，通过X射线光电子能谱（XPS）对从大鼠骨骼中取出的cpTi植入物的表面特性进行了检查。为此，将直径1.1毫米、长度3.5毫米的半圆柱形子弹植入Wistar大鼠的股骨中，然后在3小时或7天后取出。无论植入间隔如何，在取出的植入物上均观察到Ti、O、C和N元素，且吸附膜（主要是蛋白质）的厚度估计约为2.5纳米。还检测到少量的Ca和P，与羟基磷灰石相比，3小时和7天后的Ca/P原子比非常小。此外，在元素图中未发现Ca和P分布之间的相关性。总之，7天后体内植入物上未形成磷酸钙化合物。
