Herberth Gunda, Gubelt Reinhild, Röder Stefan, Krämer Ursula, Schins Roel P F, Diez Ulrike, Borte Michael, Heinrich Joachim, Wichmann H-Erich, Herbarth Olf, Lehmann Irina
UFZ - Helmholtz Centre for Environmental Research Leipzig, Department of Environmental Immunology, 04318 Leipzig, Germany.
Pediatr Allergy Immunol. 2009 Sep;20(6):563-70. doi: 10.1111/j.1399-3038.2008.00819.x. Epub 2009 May 31.
There is concern about indoor air quality as a possible cause for health impairment. Exposure to indoor renovation activities has been shown to be associated with airway symptoms and allergic manifestations in children. The aim of this study is to analyse immune markers responsible for disease development in relation to renovation activities. Within the LISAplus (Life style Immune System Allergy) birth cohort study, blood samples of 6-yr-old children were analysed for concentration of the inflammatory markers interleukin (IL)-8, IL-6, tumour necrosis factor-alpha, MCP-1 and IL-10. Data on indoor renovation activities (painting, flooring, new furniture) were assessed with a questionnaire filled in by the parents. Data on cytokine blood concentrations and exposure variables were available for 250 children. Increased levels of IL-8 and MCP-1 in children's blood were related to renovation activities. In particular, new floor covering was associated with increased inflammatory markers. Among floor covering materials only wall-to-wall carpets were associated with elevated IL-8 and Monocyte Chemoattractant Protein-1 (MCP-1) levels. No association between the single renovation activities painting and furnishing and blood concentration of inflammatory markers has been found. Our data shows that IL-8 and MCP-1 may be suitable markers for monitoring inflammatory reactions in relation with renovation activities. Among renovation activities floor covering seems to induce the strongest inflammatory reactions.
人们担心室内空气质量可能是导致健康受损的原因。研究表明，儿童接触室内装修活动与呼吸道症状及过敏表现有关。本研究的目的是分析与装修活动相关的、导致疾病发展的免疫标志物。在LISAplus（生活方式、免疫系统、过敏）出生队列研究中，对6岁儿童的血液样本进行了分析，以检测炎症标志物白细胞介素（IL）-8、IL-6、肿瘤坏死因子-α、单核细胞趋化蛋白-1（MCP-1）和IL-10的浓度。通过家长填写问卷来评估室内装修活动（油漆、地板、新家具）的数据。有250名儿童的细胞因子血液浓度和暴露变量数据。儿童血液中IL-8和MCP-1水平升高与装修活动有关。特别是，新的地板覆盖物与炎症标志物增加有关。在地板覆盖材料中，只有满铺地毯与IL-8和单核细胞趋化蛋白-1（MCP-1）水平升高有关。未发现单一的装修活动（油漆和家具）与炎症标志物血液浓度之间存在关联。我们的数据表明，IL-8和MCP-1可能是监测与装修活动相关的炎症反应的合适标志物。在装修活动中，地板覆盖似乎会引发最强的炎症反应。
