Kullich W, Klein G
Ludwig-Boltzmann-Institut für Rehabilitation interner Erkrankungen, Saalfelden.
Wien Med Wochenschr. 1991;141(15):331-5.
Early indications of the development of gastroduodenal lesions can be obtained with the radioimmunological determination of pepsinogen I in serum. The influence of the non-steroidal anti-inflammatory drug Acemetacin in depot form on the course of the pepsinogen levels in serum was examined during 14 day therapy. Mean and median of pepsinogen I in the whole group of 26 patients did not increase significantly. Likewise no increases of the single pepsinogen levels in serum were seen in 85%. Only 4 patients showed increases of about 20 to 27% compared with the initial values. These results indicate that Acemetacin with prolonged action is well tolerated and has only mean influence on the integrity of the mucosa.
通过放射免疫法测定血清中胃蛋白酶原I可获得胃十二指肠病变发展的早期迹象。在为期14天的治疗过程中，研究了长效非甾体抗炎药醋氯芬酸对血清中胃蛋白酶原水平变化过程的影响。26例患者的整个研究组中，胃蛋白酶原I的均值和中位数均未显著升高。同样，85%的患者血清中单一胃蛋白酶原水平也未见升高。与初始值相比，只有4例患者的胃蛋白酶原水平升高了约20%至27%。这些结果表明，长效醋氯芬酸耐受性良好，对黏膜完整性仅有中等程度的影响。
