Kullich W, Wallner H, Klein G
Ludwig-Boltzmann-Institut für Rehabilitation interner Erkrankungen, Saalfelden.
Wien Klin Wochenschr. 1994;106(7):208-11.
Therapy with non-steroidal anti-inflammatory drugs often causes gastroduodenal side effects. Changes in the gastric mucosa were studied by determination of serum pepsinogen I and pepsinogen II by the means of radioimmunoassay. 41 patients with degenerative rheumatic diseases were divided into two groups, 21 patients receiving 600 mg S(+) ibuprofen daily (3 x 200mg) and 20 patients receiving 900 mg S(+) ibuprofen daily (3 x 300 mg) over a 14-day period. No significant increase occurred in mean and median values of pepsinogen I and II. Indeed, no changes in serum pepsinogen I and II were noted in 80% of the patients in the higher dosage group and in more than 90% of the lower dosage group. None of the gastroduodenal side effects frequently reported during therapy with non-steroidal anti-rheumatic drugs occurred.
使用非甾体抗炎药进行治疗常常会引发胃十二指肠副作用。通过放射免疫分析法测定血清胃蛋白酶原I和胃蛋白酶原II，研究胃黏膜的变化。41例退行性风湿性疾病患者被分为两组，21例患者在14天内每日服用600毫克S（+）布洛芬（3×200毫克），20例患者在14天内每日服用900毫克S（+）布洛芬（3×300毫克）。胃蛋白酶原I和II的均值和中位数没有显著增加。实际上，高剂量组80%的患者以及低剂量组90%以上的患者血清胃蛋白酶原I和II均未出现变化。在使用非甾体抗风湿药治疗期间经常报告的胃十二指肠副作用均未发生。
