Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
Planta Med. 2009 Nov;75(14):1534-7. doi: 10.1055/s-0029-1185746. Epub 2009 Jun 4.
Phytochemical investigation of the aerial parts of Abies chensiensis afforded two new (compounds 2 and 3) and 27 known compounds, including the related compound larixinol ( 1). The structures of spirobiflavonoids 1- 3 were established using 1D and 2D NMR spectroscopic techniques. In addition, the structure of larixinol ( 1) was confirmed by X-ray crystallographic analysis. Compounds 1- 3 were evaluated for inhibitory activities against LPS-induced NO production in macrophages. Larixinol ( 1) showed moderate effects, with an IC(50) value of 60.0 microg/mL. In addition, it did not show any cytotoxicity on RAW 264.7 macrophages at 100 microg/mL.
对产自中国冷杉（Abies chensiensis）的枝叶部分的植物化学研究提供了两个新的化合物（化合物 2 和 3）和 27 个已知化合物，包括相关化合物 larixinol（1）。使用 1D 和 2D NMR 波谱技术建立了螺双黄酮类化合物 1-3 的结构。此外，通过 X 射线晶体学分析确定了 larixinol（1）的结构。评估了化合物 1-3 对 LPS 诱导的巨噬细胞中 NO 生成的抑制活性。larixinol（1）表现出中等的效果，IC50 值为 60.0μg/mL。此外，在 100μg/mL 时，它对 RAW 264.7 巨噬细胞没有任何细胞毒性。
