School of Pharmacy, Shanghai Jiao Tong University, Shanghai, PR China.
Chem Biodivers. 2011 Dec;8(12):2299-309. doi: 10.1002/cbdv.201000373.
Two new, i.e., 1 and 2, and 69 known phenolics were isolated from the aerial parts of Abies nephrolepis. These chemical constituents included 22 lignans, 30 flavonoids, and 19 other phenols. Their structures were determined mainly by analysis of the 1D- and 2D-NMR spectroscopic data. All the 71 isolates were evaluated for their inhibitory activities against lipopolysaccharide (LPS)-induced NO production in RAW 264.7 macrophages. Compound 1 exhibited a potent effect with an IC(50) value of 13.7 μg/ml.
从白皮冷杉的地上部分分离得到了两种新的化合物 1 和 2，以及 69 种已知的酚类化合物。这些化学成分包括 22 种木脂素、30 种类黄酮和 19 种其他酚类化合物。它们的结构主要通过分析 1D 和 2D-NMR 光谱数据来确定。对所有 71 种分离物进行了抑制脂多糖 (LPS) 诱导 RAW 264.7 巨噬细胞中一氧化氮 (NO) 产生的活性评价。化合物 1 表现出很强的抑制活性，IC50 值为 13.7μg/ml。
