菊科蒿属 Blumeaenes A-J，具有 NO 抑制活性的菊科蒿属倍半萜酯。
Blumeaenes A-J, sesquiterpenoid esters from Blumea balsamifera with NO inhibitory activity.
机构信息
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P R China.
出版信息
Planta Med. 2010 Jun;76(9):897-902. doi: 10.1055/s-0029-1240800. Epub 2010 Jan 25.
Chemical examination of the ethanol extract of the aerial parts of Blumea balsamifera led to the isolation of ten new sesquiterpenoid esters, blumeaenes A-J (1- 10), with 13 known flavonoids. Their structures were determined mainly by use of 1D and 2D NMR spectroscopic techniques. All sesquiterpenoid esters were tested for their inhibitory activity against LPS-induced NO production in RAW264.7 macrophages. Compounds 1, 4 and 5 showed slight inhibitory effect on the production of NO with IC(50) values of 40.06, 46.35 and 57.80 microg/mL, respectively.
从菊科植物艾纳香的地上部分的乙醇提取物中分离得到了 10 个新的倍半萜酯类化合物，命名为艾纳香烯 A-J（1-10），同时还分离得到了 13 个已知的黄酮类化合物。它们的结构主要是通过使用 1D 和 2D NMR 光谱技术来确定的。所有的倍半萜酯类化合物都被测试了对 LPS 诱导的 RAW264.7 巨噬细胞中 NO 产生的抑制活性。化合物 1、4 和 5 对 NO 的产生表现出轻微的抑制作用，IC50 值分别为 40.06、46.35 和 57.80 μg/mL。
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