Carmignani Luca, Gadda Franco, Paffoni Alessandro, Bozzini Giorgio, Stubinsky Robert, Picozzi Stefano, Rocco Francesco
Department of Urology, University of Milan, IRCCS Policlinico San Donato, Milano, Italy.
Arch Ital Urol Androl. 2009 Mar;81(1):21-3.
OBJECTIVE of the study is a prospective evaluation of the severe oligospermic and azoospermic patients at the moment of testicular cancer diagnosis and following curative therapies.
Between January 2003 and December 2006 thirty-five testicular cancers were diagnosed at our institution. As soon as a testicular mass was diagnosed patients were requested to cryo-conserve a semen specimen before orchiectomy. Overall 20 patients adhered to our recommendation. The remaining 15 patients did not follow this recommendation only due to strictly personal and psychological reasons.
Ten patients presented severe oligospermia or azoospermia at the moment of testicular cancer diagnosis. Nine months following testicular tumour removal 9 recovered or improved their fertility passing form an azoospermia status to a mean 5.68 x 10(6) spermatozoa/ml. One patient remained azoospermic.
In 1999 Petersen stated that the presence of so many infertile patients at the time of testis tumoural diagnosis was linked with defined genetic alterations in the other testis. These alterations were linked with severe oligospermia or azoospermia. Our study evidences how a considerable percentage of azoospermic and oligospermic patients recover fertility following definite testicular cancer therapies even if these are potentially harmful for spermatogenesis.
本研究的目的是对睾丸癌诊断时及根治性治疗后的严重少精子症和无精子症患者进行前瞻性评估。
2003年1月至2006年12月期间，我院诊断出35例睾丸癌。一旦诊断出睾丸肿块，要求患者在睾丸切除术前冷冻保存精液标本。共有20例患者遵循了我们的建议。其余15例患者未遵循此建议，完全是出于个人和心理原因。
10例患者在睾丸癌诊断时出现严重少精子症或无精子症。睾丸肿瘤切除9个月后，9例患者的生育能力恢复或改善，从无精子症状态转变为平均5.68×10⁶精子/毫升。1例患者仍为无精子症。
1999年彼得森指出，在睾丸肿瘤诊断时存在如此多的不育患者与另一侧睾丸的特定基因改变有关。这些改变与严重少精子症或无精子症有关。我们的研究证明，相当一部分无精子症和少精子症患者在明确的睾丸癌治疗后恢复了生育能力，即使这些治疗可能对精子发生有害。
