Li Qingning, Wang Xuemei, Lu Xiaohua, Tian Honger, Jiang Hui, Lv Gang, Guo Dadong, Wu Chunhui, Chen Baoan
State Key Lab of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing 210096, PR China.
Biomaterials. 2009 Sep;30(27):4708-15. doi: 10.1016/j.biomaterials.2009.05.015. Epub 2009 Jun 5.
Porous nanostructure with its unique properties is found to be able to hold promise in drug delivery. We fabricated the one-dimensional titanium dioxide whiskers (TiO2 Ws) and designed a strategy to explore their drug delivery application and anti-tumor function combined with daunorubicin (DNR). We observed good biocompatibility of TiO2 Ws and noted better photocatalytic activity. In human hepatocarcinoma cells (SMMC-7721 cells), TiO2 Ws can obviously increase the intracellular concentration of DNR and enhance its potential anti-tumor efficiency, indicating TiO2 Ws could produce an efficient drug delivery carrier effect importing DNR into target cells. Furthermore, its photocatalysis further led to the enhanced mortality of cancer cells under UV irradiation. These findings reveal that TiO2 Ws-based delivery of anticancer drugs represents a promising approach in cancer therapy.
具有独特性质的多孔纳米结构被发现有望用于药物递送。我们制备了一维二氧化钛晶须（TiO₂ Ws），并设计了一种策略来探索其与柔红霉素（DNR）相结合的药物递送应用和抗肿瘤功能。我们观察到TiO₂ Ws具有良好的生物相容性，并注意到其具有更好的光催化活性。在人肝癌细胞（SMMC - 7721细胞）中，TiO₂ Ws能显著提高DNR的细胞内浓度，并增强其潜在的抗肿瘤效率，表明TiO₂ Ws可产生将DNR导入靶细胞的高效药物递送载体效应。此外，其光催化作用在紫外线照射下进一步导致癌细胞死亡率增加。这些发现表明，基于TiO₂ Ws的抗癌药物递送是癌症治疗中一种有前景的方法。
