Romanchuk L A, Korshunov V M, Busch W, Ivanov A A, Tarabrina N P
Zh Mikrobiol Epidemiol Immunobiol. 1991 Jul(7):23-5.
In experiments on 406 CBA mice the effect of antimicrobial preparations, used in combination with total gnotobiotic isolation, on the survival rate of totally irradiated animals was studied. The use of antimicrobial preparations was shown to considerably enhance the survival rate of these animals. Cyprofloxacin, a new preparation of the kinolone row, exhibited a good effect ensuring selective decontamination of the intestine. The use of cyprofloxacin prior to irradiation with the subsequent isolation of the animals in gnotobiotic chambers increased the survival rate of these animals by 2.7 times. But the maximum survival rate of irradiated mice was observed in those cases when antimicrobial preparations were used both before and after irradiation in combination with the total gnotobiotic isolation of the animals.
在对406只CBA小鼠进行的实验中，研究了抗菌制剂与完全无菌隔离相结合对完全受辐照动物存活率的影响。结果表明，使用抗菌制剂可显著提高这些动物的存活率。环丙沙星是喹诺酮类的一种新制剂，具有良好的效果，可确保肠道的选择性去污。在辐照前使用环丙沙星，随后将动物置于无菌隔离室中，可使这些动物的存活率提高2.7倍。但是，当在辐照前后都使用抗菌制剂并结合对动物进行完全无菌隔离时，观察到受辐照小鼠的存活率最高。
