Romanchuk L A, Elizbarashvili D A, Ginodman G A, Korshunov V M
Zh Mikrobiol Epidemiol Immunobiol. 1991 Jun(6):4-6.
The aim of these investigations was the study of the effect of different antimicrobial preparations on the survival rate and intestinal microflora of mice with experimental acute radiation sickness. These investigations revealed that the survival rate of the animals increased 3.1 times with the use of Supramycin, 2.4 times with the use of Tacef and 1.6 times with the use of Spizef and Pen-bristol. The study of the influence of these preparations on the intestinal microflora revealed that Spizef not only decreased the number of opportunistic microorganisms, but also led to a sharp drop in the level of lactobacteria. The use of Pen-bristol and Tacef led to practically complete elimination of enterobacteria enterococci, staphylococci, as well as lactobacteria. Supramycin essentially suppressed the number of opportunistic microorganisms and did not affect the level of lactobacteria. This was probably the cause of the highest effectiveness of Supramycin in comparison with Tacef, Spizef and Pen-bristol.
这些研究的目的是研究不同抗菌制剂对实验性急性放射病小鼠存活率和肠道微生物群的影响。这些研究表明，使用硫酸新霉素时动物存活率提高了3.1倍，使用头孢氨苄时提高了2.4倍，使用Spizef和盘尼西林时提高了1.6倍。对这些制剂对肠道微生物群影响的研究表明，Spizef不仅减少了机会性微生物的数量，还导致乳酸菌水平急剧下降。使用盘尼西林和头孢氨苄实际上导致肠杆菌、肠球菌、葡萄球菌以及乳酸菌基本消除。硫酸新霉素基本上抑制了机会性微生物的数量，且不影响乳酸菌水平。这可能是硫酸新霉素比头孢氨苄、Spizef和盘尼西林效果最佳的原因。
