Comenius University, Department of Biochemistry, Bratislava, Slovak Republic.
Autophagy. 2009 Aug;5(6):872-3. doi: 10.4161/auto.9065. Epub 2009 Aug 20.
The term mitophagy refers to the selective removal of mitochondria by autophagy. This process is very active in lactate-grown yeast cells during nitrogen starvation. Among different antioxidants tested, only N-acetyl L-cysteine (NAC) prevents mitophagy in lactate-grown nitrogen-starved cells and its effect is not related to its scavenging properties, but rather to the fueling effect of the glutathione pool. In these conditions, glutathione regulates mitophagy independently of general autophagy.
自噬是指通过自噬选择性地去除线粒体。在氮饥饿时，乳酸生长的酵母细胞中的这个过程非常活跃。在测试的不同抗氧化剂中，只有 N-乙酰-L-半胱氨酸（NAC）可以防止氮饥饿的乳酸生长细胞中的自噬，其效果与其清除特性无关，而是与谷胱甘肽池的燃料效应有关。在这些条件下，谷胱甘肽独立于一般自噬来调节线粒体自噬。
