Li Yanping, Liu Wencheng, Oo Tinmarla F, Wang Lei, Tang Yi, Jackson-Lewis Vernice, Zhou Chun, Geghman Kindiya, Bogdanov Mikhail, Przedborski Serge, Beal M Flint, Burke Robert E, Li Chenjian
Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, USA.
Nat Neurosci. 2009 Jul;12(7):826-8. doi: 10.1038/nn.2349. Epub 2009 Jun 7.
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.
富含亮氨酸重复激酶2（LRRK2）的突变是帕金森病最常见的遗传病因。我们创建了一种LRRK2转基因小鼠模型，该模型概括了该疾病的主要特征：与多巴胺释放减少和黑质纹状体多巴胺能投射的轴突病理相关的年龄依赖性和左旋多巴反应性运动迟缓。这些小鼠提供了一种有效的帕金森病模型，是研究发病机制和治疗方法的资源。
