Crown J P, Jhanwar S, Haimi J, Andreef M, Gee T
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, N.Y.
Acta Haematol. 1991;86(2):103-6. doi: 10.1159/000204813.
A 62-year-old male with a history of vesical carcinoma treated with pelvic radiotherapy and cystectomy developed intermittent fevers associated with oral ulcers and neutropenia. Serial blood counts revealed cyclic haematopoiesis, with periodic neutropenia, lymphocytopenia, monocytopenia and thrombocytopenia. Bone marrow examination revealed intermittent hypoplasia without myelodysplasia or leukaemia. Marrow karyotype revealed a clonal chromosomal abnormality which included trisomy 8 and absence of the Y chromosome. We also provide evidence of spontaneous differentiation of the clonal marrow cells to mature leucocytes.
一名62岁男性，有膀胱癌病史，接受过盆腔放疗和膀胱切除术，出现间歇性发热，伴有口腔溃疡和中性粒细胞减少。连续血常规检查显示周期性造血，伴有周期性中性粒细胞减少、淋巴细胞减少、单核细胞减少和血小板减少。骨髓检查显示间歇性造血功能低下，无骨髓发育异常或白血病。骨髓核型分析显示一种克隆性染色体异常，包括8号染色体三体和Y染色体缺失。我们还提供了克隆性骨髓细胞自发分化为成熟白细胞的证据。
