Huret J L, Schoenwald M, Gabarre J, Vaugier G L, Tanzer J
Hématologie et Oncologie Médicale, CNRS URA 1338, Poitiers, France.
Acta Haematol. 1991;86(2):111-4. doi: 10.1159/000204815.
We report on 2 patients with isochromosome 21q [i(21q)] or translocation 21q21q [t(21q21q)] in myeloid disorders. Of 18 available cases of i(21q) or t(21q21q), 15 were found in myeloid malignancies, often secondary to a previous carcinogen exposure. Complex karyotypes were found in most cases. Four cases presented with i(21q) or t(21q21q) as the sole anomaly, and this might represent a specific entity.
我们报告了2例患有21号染色体等臂染色体[i(21q)]或21q21q易位[t(21q21q)]的髓系疾病患者。在18例已知的i(21q)或t(21q21q)病例中，15例见于髓系恶性肿瘤，通常继发于既往致癌物暴露。大多数病例发现有复杂的核型。4例病例以i(21q)或t(21q21q)作为唯一异常表现，这可能代表一种特殊的实体。
