Goto Yuki, Iwasaki Kazuhiro, Torikai Kohei, Murakami Hiroshi, Suga Hiroaki
Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1, Komaba, Meguro, Tokyo 153-8904, Japan.
Chem Commun (Camb). 2009 Jun 21(23):3419-21. doi: 10.1039/b904314d. Epub 2009 Apr 30.
We report here the ribosomal synthesis of methyllanthionine-containing cyclic peptides involving a site-specific incorporation of vinylglycine under the reprogrammed genetic code, followed by the isomerization of the vinylglycine to dehydrobutyrine, and the subsequent intramolecular Michael addition of a cysteine residue placed at a downstream position of the vinylglycine.
我们在此报告含甲基羊毛硫氨酸环肽的核糖体合成过程，该过程涉及在重新编程的遗传密码下乙烯基甘氨酸的位点特异性掺入，随后乙烯基甘氨酸异构化为脱氢丁氨酸，以及随后位于乙烯基甘氨酸下游位置的半胱氨酸残基的分子内迈克尔加成反应。
Zotero 插件