为代谢综合征和2型糖尿病研究选择“合适的”小鼠模型。
Selecting the "right" mouse model for metabolic syndrome and type 2 diabetes research.
作者信息
Leiter Edward H
机构信息
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
出版信息
Methods Mol Biol. 2009;560:1-17. doi: 10.1007/978-1-59745-448-3_1.
This is not a "Methods" chapter in the traditional sense. Rather, it is an essay designed to help address one of the most frequently asked questions by investigators about to embark on a study requiring an animal model of diabetes - what is the "right" model for the reader's specific research application. Because genetic heterogeneity and the requirement for complex gene-environment interaction characterize the various mouse models of Type 2 diabetes as well as the human disease manifestations, the readers may come to share the author's conclusion that more than one model is required if the investigator is interested in knowing how broadly effective a given compound with putative therapeutic efficacy might be.
这并非传统意义上的“方法”章节。相反，它是一篇旨在帮助解答即将开展一项需要糖尿病动物模型研究的研究者最常提出的问题之一的文章——对于读者的特定研究应用而言，“正确”的模型是什么。由于遗传异质性以及复杂基因 - 环境相互作用的要求是2型糖尿病的各种小鼠模型以及人类疾病表现的特征，如果研究者想要了解一种具有假定治疗效果的特定化合物可能具有多广泛的疗效，读者可能会认同作者的结论，即需要不止一种模型。
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