通过 SK0506 靶向 BuChE-炎症途径来管理 2 型糖尿病和阿尔茨海默病。
Targeting BuChE-inflammatory pathway by SK0506 to manage type 2 diabetes and Alzheimer disease.
机构信息
Department of Medical & Molecular Biosciences, Faculty of Science, University of Technology Sydney, Broadway 2007, PO Box 123, Sydney, NSW, Australia.
出版信息
Neurochem Res. 2009 Dec;34(12):2163-9. doi: 10.1007/s11064-009-0011-z.
Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) affect a large percent of the population worldwide. Experimental studies have revealed that T2DM and AD share several molecular processes that underlie their respective degenerative pathology. Based on this information, we quantified TNF-α, IL-6 levels, serum glucose, serum triglyceride, hepatic triglyceride, serum AST, serum ALT and butyrylcholinesterase (BuChE) in various rat tissues. HFD was fed to rats resulting in increased body weight, fasting blood glucose, IL-6, TNF-α levels, hepatic triglyceride, serum AST, serum ALT and BuChE. SK0506 treatment significantly prevented weight gain induced by HFD feeding. SK0506, but not Rosiglitazone, significantly reduced serum and hepatic triglycerides levels. Treatment with SK0506 also ameliorated elevated levels of both inflammatory markers (TNF-α and IL-6) and serum liver enzymes (ALT and AST) significantly in HFD fed rats. BuChE activity also reduced in skeletal muscle and adipose tissues of rats treated by SK0506. In conclusion, current study has opened new potential avenues towards research for management of T2DM and AD by Chinese herbal extracts, ‘‘SK0506’’.
2 型糖尿病（T2DM）和阿尔茨海默病（AD）影响着全世界很大一部分人口。实验研究表明，T2DM 和 AD 共享几种分子过程，这些过程是它们各自退行性病变的基础。基于这些信息，我们对各种大鼠组织中的 TNF-α、IL-6 水平、血清葡萄糖、血清甘油三酯、肝甘油三酯、血清天冬氨酸转氨酶（AST）、血清丙氨酸转氨酶（ALT）和丁酰胆碱酯酶（BuChE）进行了定量。高脂肪饮食（HFD）喂养大鼠导致体重增加、空腹血糖、IL-6、TNF-α 水平、肝甘油三酯、血清 AST、血清 ALT 和 BuChE 升高。SK0506 治疗显著预防了 HFD 喂养引起的体重增加。SK0506 可显著降低血清和肝甘油三酯水平，而罗格列酮则无此作用。SK0506 治疗还显著改善了 HFD 喂养大鼠的两种炎症标志物（TNF-α和 IL-6）和血清肝酶（ALT 和 AST）的升高水平。SK0506 还降低了大鼠骨骼肌和脂肪组织中的 BuChE 活性。总之，本研究为通过中药提取物“SK0506”来管理 T2DM 和 AD 开辟了新的潜在途径。
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