[甘草中香豆素类成分的化学研究]

[Chemical studies of coumarins from Glycyrrhiza uralensis Fisch].

作者信息

Wang C L, Zhang R Y, Han Y S, Dong X G, Liu W B

机构信息

Chemistry Department of Henan Normal University, Xinxiang.

出版信息

Yao Xue Xue Bao. 1991;26(2):147-51.

PMID:1950571

Abstract

This paper reports the isolation and identification of eight crystalline substances (I, II, III, IV, V, VI, VII, VIII) from the root of Glycyrrhiza uralensis Fisch. Besides the known compounds liquiritin, hexacosance, beta-sitosterol, licoricone liquiritigenin and etc, a new constituent, named neoglycyrol was obtained by sillica gel and polyamide column chromatographic method. Its chemical structure was elucidated by means of chemical and spectrometric analysis (UV, IR, NMR and MS). Neoglycyrol, C21H18O6, yellow needles with mp 263.5-265 degrees C, possesses one methoxyl, one isopentenyl and two hydroxyls. Its diacetate derivative is C25H22O8 with mp 202-203.5 degrees C. Its dimethyl ether derivative is C23H22O6 with mp 207-208.5 degrees C. Its structure was found to be VII.

摘要

本文报道了从甘草根中分离并鉴定出8种结晶物质（I、II、III、IV、V、VI、VII、VIII）。除了已知化合物甘草苷、二十六烷、β-谷甾醇、甘草酮、甘草素等外，通过硅胶和聚酰胺柱色谱法得到了一种新成分，命名为新甘草酚。通过化学和光谱分析（紫外、红外、核磁共振和质谱）阐明了其化学结构。新甘草酚，C21H18O6，黄色针状晶体，熔点263.5 - 265℃，含有一个甲氧基、一个异戊烯基和两个羟基。其二乙酸酯衍生物为C25H22O8，熔点202 - 203.5℃。其二甲醚衍生物为C23H22O6，熔点207 - 208.5℃。发现其结构为VII。