Li B Y, Yang B F, Li W H
Department of Pharmacology, Harbin Medical University, China.
Zhongguo Yao Li Xue Bao. 1991 Jan;12(1):48-52.
The isolated working rabbit hearts perfused with Tyrode's buffer solution persisted working in good condition at least up to 70 min. Berbamine (Ber) 3 mumol.L-1 significantly changed the hemodynamic parameters and reduced cardiac functions. The effects of Ber appeared in a dose-dependent manner. Reperfusion following 30-min of global ischemia aggravated the myocardial damages induced by ischemia, and the parameters of cardiac functions in working hearts markedly reduced and did not restore even at 20 min of reperfusion. Ber 1 mumol.L-1 reduced the myocardial ischemic reperfused damages and restored all parameters to the level of preischemia within 10 min of reperfusion, and this situation of working hearts also lasted 40-50 min. The present results showed that Ber could protect myocardium against ischemic reperfused damages, promote the recovery of cardiac functions and prolong the efficient working period in isolated working rabbit hearts.
用台氏缓冲液灌注的离体工作兔心脏至少能良好工作70分钟。小檗胺（Ber）3 μmol·L-1显著改变血流动力学参数并降低心脏功能。小檗胺的作用呈剂量依赖性。30分钟全心缺血后的再灌注加重了缺血诱导的心肌损伤，工作心脏的心脏功能参数显著降低，甚至在再灌注20分钟时仍未恢复。小檗胺1 μmol·L-1减轻了心肌缺血再灌注损伤，并在再灌注10分钟内将所有参数恢复到缺血前水平，工作心脏的这种情况也持续了40 - 50分钟。目前的结果表明，小檗胺可保护心肌免受缺血再灌注损伤，促进心脏功能恢复，并延长离体工作兔心脏的有效工作时间。
