Zegerman Philip, Diffley John F X
Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.
DNA Repair (Amst). 2009 Sep 2;8(9):1077-88. doi: 10.1016/j.dnarep.2009.04.023. Epub 2009 Jun 7.
Faithful inheritance of the genome from mother to daughter cell requires that it is replicated accurately, in its entirety, exactly once. DNA replication not only has to have high fidelity, but also has to cope with exogenous and endogenous agents that damage DNA during the life cycle of a cell. The DNA damage checkpoint, which monitors and responds to defects in the genome, is critical for the completion of replication. The focus of this review is how DNA replication is regulated by the checkpoint response in the presence of DNA damage and fork stalling agents.
基因组从母细胞到子细胞的忠实遗传要求其被精确、完整且仅复制一次。DNA复制不仅必须具有高保真度，还必须应对在细胞生命周期中损伤DNA的外源性和内源性因素。监测并响应基因组缺陷的DNA损伤检查点对于复制的完成至关重要。本综述的重点是在存在DNA损伤和叉停滞因子的情况下，DNA复制如何受到检查点反应的调控。
