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结肠隐窝中的细胞凋亡、大肠腺瘤以及化学预防的调控作用

Apoptosis in the colonic crypt, colorectal adenomata, and manipulation by chemoprevention.

作者信息

West Nicholas J, Courtney Edward D J, Poullis Andrew P, Leicester Roger J

机构信息

Endoscopy Department, St George's Hospital, London, UK.

出版信息

Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1680-7. doi: 10.1158/1055-9965.EPI-09-0006.

DOI:10.1158/1055-9965.EPI-09-0006
PMID:19505899
Abstract

This review discusses the biology and the methods of assessment of apoptosis, of which, the monoclonal antibody M30 would seem to be the most useful; the role of apoptosis in the etiology of colorectal cancer; and its use as a marker to monitor the beneficial effects of chemopreventative interventions to reduce the development of colorectal cancer within the context of clinical trials.

摘要

本综述讨论了细胞凋亡的生物学特性、评估方法（其中单克隆抗体M30似乎最为有用）；细胞凋亡在结直肠癌病因学中的作用；以及在临床试验背景下，其作为一种标志物用于监测化学预防干预措施对降低结直肠癌发生的有益效果。

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