Holland Nina, Huen Karen, Tran Vy, Street Kelly, Nguyen Brian, Bradman Asa, Eskenazi Brenda
Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, 50 University Hall, Berkeley, CA 94720-7360, USA.
Toxics. 2016 Mar;4(1). doi: 10.3390/toxics4010007. Epub 2016 Mar 14.
People are exposed to phthalates through their wide use as plasticizers and in personal care products. Many phthalates are endocrine disruptors and have been associated with adverse health outcomes. However, knowledge gaps exist in understanding the molecular mechanisms associated with the effects of exposure in early and late pregnancy. In this study, we examined the relationship of eleven urinary phthalate metabolites with isoprostane, an established marker of oxidative stress, among pregnant Mexican-American women from an agricultural cohort. Isoprostane levels were on average 20% higher at 26 weeks than at 13 weeks of pregnancy. Urinary phthalate metabolite concentrations suggested relatively consistent phthalate exposures over pregnancy. The relationship between phthalate metabolite concentrations and isoprostane levels was significant for the sum of di-2-ethylhexyl phthalate and the sum of high molecular weight metabolites with the exception of monobenzyl phthalate, which was not associated with oxidative stress at either time point. In contrast, low molecular weight metabolite concentrations were not associated with isoprostane at 13 weeks, but this relationship became stronger later in pregnancy (-value = 0.009 for the sum of low molecular weight metabolites). Our findings suggest that prenatal exposure to phthalates may influence oxidative stress, which is consistent with their relationship with obesity and other adverse health outcomes.
邻苯二甲酸盐作为增塑剂被广泛使用，并存在于个人护理产品中，人们因此接触到邻苯二甲酸盐。许多邻苯二甲酸盐是内分泌干扰物，与不良健康后果有关。然而，在理解与妊娠早期和晚期接触邻苯二甲酸盐的影响相关的分子机制方面，仍存在知识空白。在本研究中，我们调查了来自一个农业队列的墨西哥裔美国孕妇中11种尿邻苯二甲酸盐代谢物与异前列腺素（一种已确定的氧化应激标志物）之间的关系。异前列腺素水平在妊娠26周时平均比13周时高20%。尿邻苯二甲酸盐代谢物浓度表明整个孕期邻苯二甲酸盐暴露相对一致。除单苄基邻苯二甲酸盐在两个时间点均与氧化应激无关外，邻苯二甲酸二（2-乙基己基）酯总和以及高分子量代谢物总和的邻苯二甲酸盐代谢物浓度与异前列腺素水平之间的关系显著。相比之下，低分子量代谢物浓度在13周时与异前列腺素无关，但在妊娠后期这种关系变得更强（低分子量代谢物总和的P值 = 0.009）。我们的研究结果表明，产前接触邻苯二甲酸盐可能会影响氧化应激，这与其与肥胖及其他不良健康后果的关系一致。
