Imperial College Kidney and Transplant Institute, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK,
Purinergic Signal. 2009 Dec;5(4):513-20. doi: 10.1007/s11302-009-9153-3. Epub 2009 Jun 9.
Our knowledge and understanding of the P2 receptor signalling system in the kidney have increased significantly in the last ten years. The broad range of physiological roles proposed for this receptor system and the variety of P2 receptor subtypes found in the kidney suggest that any disturbance of function may contribute to several pathological processes. So far, most reports of a possible pathophysiological role for this system in the kidney have focussed on polycystic kidney disease, where abnormal P2 receptor signalling might be involved in cyst expansion and disease progression, and on the P2X(7) receptor, a unique P2X subtype, which when activated enhances inflammatory cytokine release and production, and also cell death. Expression of this particular receptor is upregulated in some forms of chronic renal injury and inflammatory diseases. Further studies of adenosine triphosphate signalling and P2 receptor expression in renal disorders could provide us with novel insights into the role of these receptors in both normal and abnormal kidney function.
在过去的十年中，我们对肾脏 P2 受体信号系统的认识和理解有了显著提高。该受体系统所提出的广泛的生理作用以及在肾脏中发现的各种 P2 受体亚型表明，任何功能障碍都可能导致多种病理过程。到目前为止，关于该系统在肾脏中可能的病理生理作用的大多数报道都集中在多囊肾病上，其中异常的 P2 受体信号可能参与囊肿扩张和疾病进展，以及 P2X(7)受体上，这是一种独特的 P2X 亚型，当其被激活时会增强炎症细胞因子的释放和产生，以及细胞死亡。这种特定受体的表达在某些形式的慢性肾损伤和炎症性疾病中上调。对肾脏疾病中三磷酸腺苷信号和 P2 受体表达的进一步研究可以为我们提供关于这些受体在正常和异常肾功能中的作用的新见解。
