Mathieu Mareike, Schunk Daniel, Franzka Steffen, Mayer Christian, Hasselbrink Eckart, Hartmann Nils
Fachbereich Chemie Physikalische Chemie and CeNIDE-Center for Nanointegration Duisburg-Essen, Universität Duisburg-Essen, Essen, Germany.
Small. 2009 Sep;5(18):2099-104. doi: 10.1002/smll.200801933.
Direct laser patterning of supported phospholipid multilayers is investigated. Spin coating is used to fabricate stacked bilayers of 1,2-dioleoyl-sn-glycero-3-phosphate (DOPA). Photothermal processing with a focused laser beam at lambda = 514 nm allows removal of the coating at predefined positions without causing any significant change in adjacent areas. Moreover, processing with nanoscale precision is feasible despite the soft and fluid nature of phospholipid films. In particular, holes with diameters from 1.8 microm down to 300 nm and below are fabricated by using a 1/e(2) laser spot size of about 2.5 microm. In addition, patterning is also very flexible and can be carried out over macroscopic length scales and at short processing times. Considering these features photothermal laser processing constitutes a powerful tool for micro- and nanopatterning of phospholipid films.
研究了支撑磷脂多层膜的直接激光图案化。采用旋涂法制备了1,2 - 二油酰 - sn - 甘油 - 3 - 磷酸（DOPA）的堆叠双层膜。使用波长λ = 514 nm的聚焦激光束进行光热加工，可以在预定位置去除涂层，而不会在相邻区域引起任何显著变化。此外，尽管磷脂膜具有柔软和流体的性质，但实现纳米级精度的加工是可行的。特别地，通过使用约2.5微米的1/e(2)激光光斑尺寸，制造出了直径从1.8微米到300纳米及以下的孔洞。此外，图案化也非常灵活，可以在宏观长度尺度上进行，并且加工时间短。考虑到这些特性，光热激光加工构成了一种用于磷脂膜微纳图案化的强大工具。
