Cho C H
Department of Pharmacology, Faculty of Medicine, University of Hong Kong.
Agents Actions. 1991 Jul;33(3-4):378-81. doi: 10.1007/BF01986589.
The electrophysiological effects of mucosal or submucosal ethanol (5, 10, or 20%) were assessed in isolated stomach preparation. Mucosal incubation with these concentrations of ethanol dose- and time-dependently decreased the transmucosal potential difference (PD), while the electrical current (I) and resistance (R) were unaffected. Submucosal exposure to the same concentrations of ethanol also reduced the PD, but to a lesser extent; only 20% of ethanol produced a significant effect. This same dose of ethanol not only decreased I but also increased R to a significant level. These findings indicate that transmucosal PD appears to be generated largely by the mucosal epithelial cell barrier, while the I and R are elicited by the laminea propria mucosa which is easily approached and altered by ethanol which acts from the submucosal side. The significance of the effects produced by mucosal or submucosal ethanol is discussed.
在离体胃标本中评估了黏膜或黏膜下给予乙醇（5%、10%或20%）的电生理效应。用这些浓度的乙醇进行黏膜孵育，经黏膜电位差（PD）呈剂量和时间依赖性降低，而电流（I）和电阻（R）未受影响。黏膜下暴露于相同浓度的乙醇也会降低PD，但程度较小；只有20%的乙醇产生显著作用。相同剂量的乙醇不仅降低了I，还使R显著升高。这些发现表明，经黏膜PD似乎主要由黏膜上皮细胞屏障产生，而I和R则由黏膜固有层引起，乙醇从黏膜下侧作用时，黏膜固有层容易受到影响并发生改变。讨论了黏膜或黏膜下乙醇产生的效应的意义。
