Biggerstaff R J, Leitch G J
Am J Dig Dis. 1977 Dec;22(12):1064-8. doi: 10.1007/BF01072858.
The gastric transmural electrical potential difference (PD) and direct-current resistance were measured in the rat in vivo under conditions in which the luminal pH was controlled over the pH range 1.0 to 12.0. Raising the pH above 11.0 caused a reduction in both PD and resistance. This is consistent with basic groups limiting cation permeability through the mucosa. Exposure of the mucosa to 20% ethanol caused a reduction in resistance, PD, and H+ secretion, and an increased appearance of Na+ in the lumen at neutral pH. The pH dependence of the resistance at high pH values was also eliminated, consistent with the elimination or bypassing of channels containing basic groups. Mucosal exposure to 8.5% ethanol reduced the PD and H+ secretion without affecting resistance. The increased appearance of Na+ in the lumen seen with this alcohol solution also occurred following exposure to hyperosmotic sucrose.
在管腔pH值控制在1.0至12.0范围内的条件下，对大鼠体内的胃跨壁电势差（PD）和直流电阻进行了测量。将pH值提高到11.0以上会导致PD和电阻降低。这与碱性基团限制阳离子透过黏膜的通透性是一致的。将黏膜暴露于20%乙醇会导致电阻、PD和H⁺分泌减少，并且在中性pH值下管腔中Na⁺的出现增加。高pH值下电阻的pH依赖性也消失了，这与含有碱性基团的通道被消除或绕过是一致的。黏膜暴露于8.5%乙醇会降低PD和H⁺分泌，但不影响电阻。用这种酒精溶液观察到的管腔中Na⁺出现增加的情况在暴露于高渗蔗糖后也会发生。
