Shibata R, Kimura M, Takahashi H, Mikami K, Aiba Y, Takeda H, Koga Y
Department of Pediatrics, Fukuoka National Hospital, Fukuoka, Japan.
Clin Exp Allergy. 2009 Sep;39(9):1397-403. doi: 10.1111/j.1365-2222.2009.03295.x. Epub 2009 Jun 8.
Oligosaccharides may have beneficial properties of the prevention of atopic dermatitis (AD). Kestose, a fructo-oligosaccharide, stimulates the activity of bifidobacteria.
To assess the clinical effect of kestose on the treatment of AD in infants.
A randomized, double-blind, placebo-controlled trial was carried out using 15 and 14 infants with AD in the kestose group and placebo groups, respectively. One to 2 g kestose and maltose were administered to the subjects in the kestose and placebo groups, respectively, everyday for 12 weeks. Clinical evaluations of AD using Severity Scoring of Atopic Dermatitis (SCORAD) and the enumeration of bifidobacteria in the feces using real-time PCR were performed at Weeks 0, 6, and 12.
The medians of the SCORAD score were significantly lower in the kestose group than in the placebo group on both Week 6 (25.3 vs. 36.4; P=0.004) and Week 12 (19.5 vs. 37.5; P<0.001). No significant correlation was found between the improvement of the SCORAD score and the count of bifidobacteria.
Kestose was found to exert a beneficial effect on the clinical symptoms in infants with AD. The mechanism how does kestose improve the symptoms of AD remains to be elucidated.
低聚糖可能具有预防特应性皮炎（AD）的有益特性。蔗果三糖，一种果寡糖，可刺激双歧杆菌的活性。
评估蔗果三糖对婴儿AD治疗的临床效果。
进行了一项随机、双盲、安慰剂对照试验，蔗果三糖组和安慰剂组分别有15名和14名AD婴儿。蔗果三糖组和安慰剂组的受试者分别每天服用1至2克蔗果三糖和麦芽糖，持续12周。在第0、6和12周使用特应性皮炎严重程度评分（SCORAD）对AD进行临床评估，并使用实时PCR对粪便中的双歧杆菌进行计数。
在第6周（25.3对36.4；P = 0.004）和第12周（19.5对37.5；P < 0.001），蔗果三糖组的SCORAD评分中位数均显著低于安慰剂组。SCORAD评分的改善与双歧杆菌计数之间未发现显著相关性。
发现蔗果三糖对AD婴儿的临床症状有有益作用。蔗果三糖改善AD症状的机制仍有待阐明。
