Department of Dermatology, St George Hospital, Sydney, NSW, Australia.
Clin Exp Dermatol. 2009 Dec;34(8):e564-6. doi: 10.1111/j.1365-2230.2009.03236.x. Epub 2009 Jun 5.
A 56-year-old man with recalcitrant psoriasis was treated with efalizumab, resulting in complete clearing of his skin lesions. However, multiple brown patches and papules, in the exact distribution of the previous psoriasis plaques, appeared on his lower legs. The pathological diagnosis was seborrhoeic keratoses (SKs) with overlapping features of solar lentigo. A variety of cutaneous adverse events has been observed in patients with psoriasis treated with efalizumab. To our knowledge, appearance of SKs after such treatment has not previously been reported. This may be due to the clinical insignificance of these benign skin tumours. However, it may be speculated whether efalizumab has an unknown effect in triggering the development of SKs in patients with psoriasis, and if this could shed any light on the pathogenesis of SKs.
一位 56 岁的男性银屑病患者接受依氟鸟氨酸治疗，导致其皮肤病变完全清除。然而，他的小腿上出现了多个棕色斑块和丘疹，分布与之前银屑病斑块完全一致。病理诊断为脂溢性角化病（SK），具有日光性雀斑的重叠特征。接受依氟鸟氨酸治疗的银屑病患者已观察到多种皮肤不良事件。据我们所知，此类治疗后出现 SK 以前尚未报道过。这可能是由于这些良性皮肤肿瘤的临床意义不大。但是，可以推测依氟鸟氨酸是否对银屑病患者 SK 的发展具有未知的影响，以及这是否能为 SK 的发病机制提供一些线索。
