Bujoreanu Florin Ciprian, Radaschin Diana Sabina, Badea Mihail Alexandru, Bujoreanu Bezman Laura, Pantiș Carmen, Tiutiuca Carmen, Baroiu Liliana, Niculeț Elena, Pleșea Condratovici Alina, Tatu Alin Laurențiu
Department of Dermatology, "Saint Parascheva" Infectious Disease Clinical Hospital, 800179 Galati, Romania.
Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800385 Galati, Romania.
Life (Basel). 2025 Mar 17;15(3):485. doi: 10.3390/life15030485.
Psoriasis is one of the most frequent immune-mediated chronic inflammatory cutaneous disease that exerts a considerable psychological impact, including low self-esteem, stigmatization, and depression. In recent years, biologic therapies have substantially transformed the therapeutic landscape for individuals with moderate-to-severe psoriasis, shifting treatment towards a more targeted and personalized approach. Seborrheic keratoses (SKs) are common benign skin lesions, and their association with psoriasis and biologic therapy remains poorly understood. Our retrospective study evaluated a small cohort of patients with moderate-to-severe psoriasis undergoing biologic therapy at a tertiary dermatology center in Southeastern Europe to evaluate potential correlations with SK development. Smokers had fewer SKs, whereas postmenopausal women and osteoporosis patients had significantly higher SK counts, implicating hormonal influences. PUVA therapy was linked to an increased SK count, whereas UVB and methotrexate treatments had a lesser effect. These findings suggest that biologic therapy and systemic factors may influence SK development, emphasizing the need for further prospective research.
银屑病是最常见的免疫介导性慢性炎症性皮肤病之一，会对心理产生相当大的影响，包括自卑、被污名化和抑郁。近年来，生物疗法极大地改变了中重度银屑病患者的治疗格局，使治疗朝着更具针对性和个性化的方向发展。脂溢性角化病（SKs）是常见的良性皮肤病变，其与银屑病及生物疗法之间的关联仍知之甚少。我们的回顾性研究评估了东南欧一家三级皮肤病中心一小群接受生物疗法的中重度银屑病患者，以评估与SK发生的潜在相关性。吸烟者的SKs较少，而绝经后女性和骨质疏松症患者的SK计数显著更高，这表明存在激素影响。补骨脂素紫外线A（PUVA）疗法与SK计数增加有关，而紫外线B（UVB）和甲氨蝶呤治疗的影响较小。这些发现表明生物疗法和全身因素可能会影响SK的发生，强调了进一步进行前瞻性研究的必要性。
