Kalender Ali Murat, Dogan Ali, Bakan Vedat, Yildiz Huseyin, Gokalp Mehmet Ata, Kalender Mahmut
Department of Orthopedics and Traumatology, Kahramanmaras Sutcu Imam University, Medical Faculty, K. Maras, Turkey.
J Brachial Plex Peripher Nerve Inj. 2009 Jun 9;4:6. doi: 10.1186/1749-7221-4-6.
Zofenopril is an antioxidant agent which has been shown to have beneficial effects in hypertension and heart failure. The aim of this study was to test the effects of Zofenopril on nerve regeneration and scarring in a rat model of peripheral nerve crush injury.
Twenty-one adult Sprague-Dawley rats underwent a surgical procedure involving right sciatic nerve crush injury. 15 mg/kg Zofenopril was administered orally to seven rats in group Z for seven days. Seven rats in group S received saline orally for seven days. Seven rats in the control group C received no drug after crush injury. Fourteenth and 42nd days after injury, functional and electromyography assessments of nerves were performed. Functional recovery was analyzed using a walking track assessment, and quantified using the sciatic functional index (SFI). After these evaluations, all rats were sacrificed and microscopic evaluations were performed.
The Sciatic functional Index (SFI) in group Z on 14th day is different significantly from group S and group C (p = 0.037). But on 42nd day there was no difference between groups (p = 0.278). The statistical analyses of electromyelographic (EMG) studies showed that the latency in group Z is significantly different from group S (p = 0.006) and group C (p = 0.045). But on 42nd day there was no difference between groups like SFI (p = 0.147). The amplitude was evaluated better in group Z than others (p < 0.05). In microscopic evaluation, we observed the highest number of nerve regeneration in the group Z and the lowest in the group C. But it was not significant statistically.
Our results demonstrate that Zofenopril promotes the regeneration of peripheral nerve injuries in rat models.
佐芬普利是一种抗氧化剂，已被证明在高血压和心力衰竭方面具有有益作用。本研究的目的是在大鼠周围神经挤压伤模型中测试佐芬普利对神经再生和瘢痕形成的影响。
21只成年Sprague-Dawley大鼠接受了涉及右侧坐骨神经挤压伤的外科手术。Z组的7只大鼠口服15mg/kg佐芬普利，持续7天。S组的7只大鼠口服生理盐水，持续7天。对照组C的7只大鼠在挤压伤后不接受药物治疗。在损伤后的第14天和第42天，对神经进行功能和肌电图评估。使用行走轨迹评估分析功能恢复情况，并使用坐骨神经功能指数（SFI）进行量化。在这些评估之后，所有大鼠均被处死并进行显微镜评估。
Z组在第14天的坐骨神经功能指数（SFI）与S组和C组有显著差异（p = 0.037）。但在第42天，各组之间没有差异（p = 0.278）。肌电图（EMG）研究的统计分析表明，Z组的潜伏期与S组（p = 0.006）和C组（p = 0.045）有显著差异。但在第42天，各组之间与SFI一样没有差异（p = 0.147）。Z组的振幅评估优于其他组（p < 0.05）。在显微镜评估中，我们观察到Z组的神经再生数量最多，C组最少。但在统计学上不显著。
我们的结果表明，佐芬普利可促进大鼠模型中周围神经损伤的再生。
