Department of Medical Education, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey.
Department of Family Medicine, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey.
Neural Regen Res. 2014 May 15;9(10):1020-4. doi: 10.4103/1673-5374.133163.
Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved significantly. These findings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats.
几项研究表明，左旋肉碱对糖尿病大鼠受损坐骨神经具有神经保护作用。据推测，左旋肉碱对糖尿病大鼠受损坐骨神经具有神经保护作用。通过钳子夹伤大鼠坐骨神经，使其产生退行性变化。连续灌胃 50 和 100mg/kg 左旋肉碱 30 天，损伤坐骨神经的轴突面积、髓鞘面积、轴突直径、髓鞘直径和有髓神经轴突数密度与正常相似，损伤坐骨神经的功能也明显改善。这些发现表明，左旋肉碱对大鼠坐骨神经钳夹伤具有神经保护作用。
