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实性角膜皮样瘤和结膜下脂质皮样瘤:不同手术治疗对长期功能预后的影响

Solid corneal dermoids and subconjunctival lipodermoids: impact of differentiated surgical therapy on the functional long-term outcome.

作者信息

Stergiopoulos Petros, Link Barbara, Naumann Gottfried O H, Seitz Berthold

机构信息

Department of Ophthalmology, University of Erlangen-Nürnberg, Erlangen, Germany.

出版信息

Cornea. 2009 Jul;28(6):644-51. doi: 10.1097/ICO.0b013e3181914305.

Abstract

PURPOSE

The functional long-term outcome after differentiated surgical therapy of solid corneal dermoids and subconjunctival lipodermoids with special regard to determinants for amblyopia will be assessed.

METHODS

Forty-six consecutive patients undergoing surgery for solid epibulbar dermoids, subconjunctival lipodermoids, or both were included. Visual acuity, refraction, keratometry, and degree of amblyopia were determined. Surgical therapy for corneal dermoids consisted of lamellar sclerokeratectomy, lamellar keratoplasty, corneoscleroplasty, and lamellar removal with autologous episcleral transplant. Surgical therapy for lipodermoids consisted of excision and reduction of the volume of the tumor. Follow-up examination was performed on average 4.5 years after surgical intervention.

RESULTS

A significant correlation between tumor volume and preoperative visual acuity could be observed in patients with solid corneal dermoids not occluding the optical axis. Visual acuity improved significantly from 0.21 +/- 0.4 to 0.35 +/- 0.4 after surgery of corneal dermoids. Most eyes had concomitant hyperopia. Postoperative visual acuity correlated positively with preoperative visual acuity (P = 0.0001). After tumor excision, hyperopia and astigmatism were not reduced significantly on average. Nineteen of 47 patients suffered from amblyopia. Amblyopia was more often observed in patients with preoperative hyperopia > or =2 diopters and astigmatism >2 diopters. Visual acuity, refraction, and astigmatism were not changed significantly by surgery in patients with subconjunctival lipodermoids.

CONCLUSIONS

Epibulbar dermoids require differentiated surgical therapy. Amblyopia is a major threat of solid corneal dermoids. The incidence of amblyopia seems to depend on preoperative occlusion of the optical axis and preoperative degree of hyperopia and astigmatism.

摘要

目的

评估实体性角膜皮样瘤和结膜下脂质皮样瘤经差异化手术治疗后的长期功能转归,尤其关注弱视的决定因素。

方法

纳入46例连续接受实体性眼球表面皮样瘤、结膜下脂质皮样瘤或两者手术的患者。测定视力、屈光、角膜曲率和弱视程度。角膜皮样瘤的手术治疗包括板层巩膜角膜切除术、板层角膜移植术、角膜巩膜成形术以及自体巩膜移植的板层切除。脂质皮样瘤的手术治疗包括肿瘤切除及体积缩小。手术干预后平均随访4.5年。

结果

在未遮挡视轴的实体性角膜皮样瘤患者中,可观察到肿瘤体积与术前视力之间存在显著相关性。角膜皮样瘤手术后视力从0.21±0.4显著提高至0.35±0.4。大多数眼睛伴有远视。术后视力与术前视力呈正相关(P = 0.0001)。肿瘤切除后,平均远视和散光未显著降低。47例患者中有19例患有弱视。术前远视≥2屈光度且散光>2屈光度的患者更常出现弱视。结膜下脂质皮样瘤患者手术前后视力、屈光和散光无显著变化。

结论

眼球表面皮样瘤需要差异化手术治疗。弱视是实体性角膜皮样瘤的主要威胁。弱视的发生率似乎取决于术前视轴遮挡情况以及术前远视和散光程度。

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