Li Nan, Qin Lu-Ping, Han Ting, Wu Yan-Bin, Zhang Qiao-Yan, Zhang Hong
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Molecules. 2009 Jun 8;14(6):2049-61. doi: 10.3390/molecules14062049.
The present study was undertaken to investigate the protective effects of ethanol extract from the root of Morinda Officinalis (RMO) on ovariectomy-induced bone loss. Administration of RMO extract increased trabecular bone mineral content and bone mineral density of tibia, improved the levels of phosphorus (P), calcium (Ca) and OPG, decreased the levels of DPD/Cr, TRAP, ACTH and corticosterone, but did not reverse the levels of ALP, TNF-alpha and IL-6 in serum of ovariectomized rats. These findings demonstrated that RMO extract reduced bone loss in ovariectomized rats, probably via the inhibition of bone resorption, but was not involved with bone formation. Anthraquinones and polysaccharides from Morinda officinals could be responsible for their antiosteoporotic activity, and the action mechanism of these constituents needs to be further studied. Therefore, RMO has the potential to develop a clinically useful antiosteoporotic agent.
本研究旨在探讨巴戟天根乙醇提取物（RMO）对去卵巢诱导的骨质流失的保护作用。给予RMO提取物可增加胫骨的小梁骨矿物质含量和骨矿物质密度，改善磷（P）、钙（Ca）和骨保护素（OPG）水平，降低脱氧吡啶啉/肌酐（DPD/Cr）、抗酒石酸酸性磷酸酶（TRAP）、促肾上腺皮质激素（ACTH）和皮质酮水平，但并未逆转去卵巢大鼠血清中碱性磷酸酶（ALP）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）的水平。这些结果表明，RMO提取物可能通过抑制骨吸收减少去卵巢大鼠的骨质流失，但与骨形成无关。巴戟天中的蒽醌类化合物和多糖可能是其抗骨质疏松活性的原因，这些成分的作用机制有待进一步研究。因此，RMO有潜力开发成为临床上有用的抗骨质疏松药物。
