Ouertani A, Tounsi L, Khammari C, Bouden J, Mili-Boussen I
Service d'ophtalmologie, hôpital Charles Nicolle, Tunis, Tunisie.
J Fr Ophtalmol. 2009 Jan;32(1):50-5. doi: 10.1016/j.jfo.2008.11.003. Epub 2009 Feb 4.
To comparatively evaluate the optic nerve head (ONH) using the confocal scanning laser ophthalmoscope (CSLO) in normal eye subjects (NE) versus big cup (BC) patients.
A total of 83 NEs (43 subjects) and 44 BC eyes (22 patients) were evaluated in this prospective study. The ONH was imaged using the CSLO (HRT-II; Heidelberg Engineering, Heidelberg, Germany). Disc area, cup area, rim area, rim volume (horizontal integrated rim volume), cup/disc ratio, and cup volume were evaluated. Additionally, cup depth and retinal nerve fiber layer thickness (RNFL th) and csa (RNFL csa) of the ONH were also measured. These ONH parameters were compared between normal subjects and eyes with a big cup. We used the t test for statistical analysis.
The mean age was 46 and 44 years in the NE and BC groups, with a sex ratio of 1.26 and 0.69 (p=0.381), respectively. There was a significant difference in disc area (2.07+/-0.38, 2.73+/-0.45, p<0.01), cup area (0.52+/-0.8, 1.26+/-0.3, p<0.01), cup volume (0.14+/-0.14, 0.44+/-0.16, p<0.01), cup/disc ratio (0.24+/-0.1, 0.69+/-0.1, 0.46+/-0.06, p<0.01), Me cup disc (0.24+/-0.1, 0.37+/-0.1, p<0.01), rim volume (0.44+/-0.1, 0.34+/-0.09, p<0.01), rim area (1.56+/-0.27, 1.45+/-0.27, p=0.345), RNFL th (0.28+/-0.05, 0.23+/-0.05, p<0.001) and CSM-0.19+/-0.14,-0.08+/-0.06, p<0.001), RNFL csa (1.43+/-0.25, 1.37+/-0.29, p=0.849) in normal vs big cup eyes, respectively.
There is correlation between the cup and disc areas. Parameters evaluating the retinal nerve fiber were comparable in the two groups, except the RNFL thickness, which was lower in the BC group. This may be explained by the larger surface of the optic disc in this group.
HRT parameters might be part of the criteria favoring the physiologic character of big cups.
使用共焦扫描激光检眼镜（CSLO）对正常眼受试者（NE）和大视杯（BC）患者的视神经乳头（ONH）进行比较评估。
在这项前瞻性研究中，共评估了83名正常眼受试者（43名受试者）和44只大视杯眼（22名患者）。使用CSLO（HRT-II；德国海德堡海德堡工程公司）对视神经乳头进行成像。评估视盘面积、视杯面积、视盘边缘面积、视盘边缘体积（水平整合视盘边缘体积）、视杯/视盘比和视杯体积。此外，还测量了视杯深度、视网膜神经纤维层厚度（RNFL th）和视神经乳头的横截面积（RNFL csa）。比较正常受试者和大视杯眼的这些视神经乳头参数。我们使用t检验进行统计分析。
正常眼组和大视杯组的平均年龄分别为46岁和44岁，性别比分别为1.26和0.69（p = 0.381）。正常眼与大视杯眼在视盘面积（2.07±0.38，2.73±0.45，p < 0.01）、视杯面积（0.52±0.8，1.26±0.3，p < 0.01）、视杯体积（0.14±0.14，0.44±0.16，p < 0.01）、视杯/视盘比（0.24±0.1，0.69±0.1，0.46±0.06，p < 0.01）、平均视杯视盘比（0.24±0.1，0.37±0.1，p < 0.01）、视盘边缘体积（0.44±0.1，0.34±0.09，p < 0.01）、视盘边缘面积（1.56±0.27，1.45±0.27，p = 0.345）、视网膜神经纤维层厚度（0.28±0.05，0.23±0.05，p < 0.001）和CSM（-0.19±0.14，-0.08±0.06，p < 0.001）、视网膜神经纤维层横截面积（1.43±0.25，1.37±0.29，p = 0.849）方面存在显著差异。
视杯和视盘面积之间存在相关性。除视网膜神经纤维层厚度在大视杯组较低外，两组中评估视网膜神经纤维的参数具有可比性。这可能是由于该组视盘表面较大所致。
HRT参数可能是支持大视杯生理性特征标准的一部分。
