Saito Hitomi, Tomidokoro Atsuo, Tomita Goji, Araie Makoto, Wakakura Masato
Department of Ophthalmology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
Ophthalmology. 2008 Sep;115(9):1585-90. doi: 10.1016/j.ophtha.2008.01.012. Epub 2008 Mar 14.
To compare optic disc morphologic features and peripapillary retinal nerve fiber layer (RNFL) thickness between the unaffected eyes of patients with unilateral nonarteritic anterior ischemic optic neuropathy (NAION) and their affected eyes and the eyes of age- and refraction-matched normal control subjects.
Cross-sectional comparative study.
Thirty-one patients with unilateral NAION and 62 age- and refraction-matched normal control subjects.
Optic disc morphologic features and peripapillary RNFL thickness were evaluated in both eyes of patients with unilateral NAION and in one randomly chosen eye of the normal control subjects.
Optic disc and cup parameters were measured using the Heidelberg Retina Tomograph II (Heidelberg Engineering GmbH, Dossenheim, Germany), and RNFL thickness was measured by scanning laser polarimetry with variable corneal compensation (GDx VCC; Carl Zeiss Meditec, Dublin, CA).
There was no significant difference in the disc area between the NAION affected eyes and the unaffected fellow eyes. The cup area, cup-to-disc area ratio, cup volume, and cup shape measure were greater, whereas the peripapillary RNFL thickness was smaller in the former than the latter (P = 0.001 to approximately 0.043). When the unaffected eyes of patients with NAION and the age- and refraction-matched normal control eyes were compared, the disc area, cup area, cup-to-disc area ratio, cup volume, mean cup depth, and cup shape measure were smaller in the former (P = 0.0006 to approximately 0.03); there was no significant difference in the RNFL thickness between the two (P>0.06).
A comparison of the eyes with NAION and the fellow eyes indicated that the cup was slightly larger in the former than in the latter, suggesting the acquired enlargement of the cupping after NAION develops. A comparison of the unaffected fellow eyes in patients with NAION and the age- and refraction-matched normal control eyes suggested that a smaller disc area and smaller cupping were predisposing risk factors for the development of NAION.
比较单侧非动脉炎性前部缺血性视神经病变（NAION）患者未受影响眼与受影响眼以及年龄和屈光匹配的正常对照者眼睛的视盘形态特征和视乳头周围视网膜神经纤维层（RNFL）厚度。
横断面比较研究。
31名单侧NAION患者和62名年龄及屈光匹配的正常对照者。
对单侧NAION患者的双眼以及正常对照者随机选取的一只眼睛进行视盘形态特征和视乳头周围RNFL厚度评估。
使用海德堡视网膜断层扫描仪II（德国多森海姆海德堡工程有限公司）测量视盘和视杯参数，通过带可变角膜补偿的扫描激光偏振仪（GDx VCC；加利福尼亚州都柏林卡尔蔡司医疗技术公司）测量RNFL厚度。
NAION受影响眼与未受影响的对侧眼之间的视盘面积无显著差异。前者的视杯面积、杯盘面积比、视杯体积和视杯形状测量值更大，而视乳头周围RNFL厚度更小（P = 0.001至约0.043）。当比较NAION患者的未受影响眼与年龄和屈光匹配的正常对照眼时，前者的视盘面积、视杯面积、杯盘面积比、视杯体积、平均视杯深度和视杯形状测量值更小（P = 0.0006至约0.03）；两者之间的RNFL厚度无显著差异（P>0.06）。
NAION患眼与对侧眼的比较表明，前者的视杯略大于后者，提示NAION发生后视杯获得性扩大。NAION患者未受影响的对侧眼与年龄和屈光匹配的正常对照眼的比较表明，较小的视盘面积和较小的视杯是NAION发生的易感危险因素。
