Donders Centre for Cognition, Radboud University Nijmegen, The Netherlands.
Epilepsia. 2009 Dec;50(12):2538-48. doi: 10.1111/j.1528-1167.2009.02162.x. Epub 2009 Jun 10.
A nonlinear association and a source localization technique were used to describe the onset and propagation of spike-and-slow-wave discharges (SWDs) in children with absence seizures. Previous studies have emphasized a leading cortical role in the generation of absence seizures in genetic epileptic rats.
Synchronization between all magnetoencephalography (MEG) sensor-couples before and during SWDs in five patients was investigated over time. A source localization [beamformer, SAM(g(2))] technique was used to find brain regions associated with the origin of the spikes of the SWDs.
The onset of SWDs was characterized by high associations at left and right frontal regions. An alternating pattern of high synchronization was found during trains of SWDs: generalized during the wave and localized during the spike; the origin of the spike was different from the onset of SWDs, more frontal lateral and medial parietal. The localization of this latter region was confirmed with SAM(g(2)).
The outcome of the nonlinear association techniques demonstrated that SWDs have a local cortical onset, whereas the association and beamformer technique support a local or even a focal cortical involvement in the occurrence of the spike in a train of SWDs. In all, the cortex contains local frontal and parietal sites relevant before the onset of the generalized pattern of SWDs and other ones that might contain the driving force behind the spike in trains of 3-4 Hz SWDs.
采用非线性关联和源定位技术描述儿童失神性癫痫发作中棘慢波放电（SWD）的起始和传播。先前的研究强调了遗传癫痫大鼠发作中皮质的主导作用。
在 5 名患者的 SWD 前后，对所有脑磁图（MEG）传感器对之间的同步性进行了时间上的研究。采用源定位（波束形成器，SAM(g(2))）技术来寻找与 SWD 棘波起源相关的脑区。
SWD 的起始特征是左右额区的高关联。在 SWD 波的过程中发现了一种交替的高同步模式：在波中表现为广泛同步，在棘波中表现为局部同步；棘波的起源与 SWD 的起始不同，更偏向额侧和顶叶内侧。SAM(g(2)) 证实了这一区域的定位。
非线性关联技术的结果表明，SWD 具有局部皮质起始，而关联和波束形成技术支持在 SWD 波的棘波中存在局部或甚至局灶性皮质参与。总之，皮质包含与 SWD 广义模式起始之前相关的局部额顶区，以及可能包含 3-4 Hz SWD 波中棘波驱动力的其他区域。
