University of California, Los Angeles - Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90095-7076, USA.
Brain Behav Immun. 2010 Jan;24(1):54-7. doi: 10.1016/j.bbi.2009.06.001. Epub 2009 Jun 9.
Sleep disturbance is associated with inflammation and related disorders including cardiovascular disease, arthritis, and diabetes mellitus. Given sex differences in the prevalence of inflammatory disorders with stronger associations in females, this study was undertaken to test the effects of sleep loss on cellular mechanisms that contribute to proinflammatory cytokine activity. In 26 healthy adults (11 females; 15 males), monocyte intracellular proinflammatory cytokine production was repeatedly assessed at 08:00, 12:00, 16:00, 20:00, and 23:00h during a baseline period and after partial sleep deprivation (awake from 23:00 to 3.00h). In the morning after a night of sleep loss, monocyte production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) differentially changed between the two sexes. Whereas both females and males showed a marked increase in the lipopolysaccharide (LPS) - stimulated production of IL-6 and TNF-alpha in the morning immediately after PSD, production of these cytokines during the early- and late evening was increased in the females as compared to decreases in the males. Sleep loss induces a functional alteration of monocyte proinflammatory cytokine responses with females showing greater cellular immune activation as compared to changes in males. These results have implications for understanding the role of sleep disturbance in the differential risk profile for inflammatory disorders between the sexes.
睡眠障碍与炎症和相关疾病有关，包括心血管疾病、关节炎和糖尿病。鉴于炎症性疾病在女性中的患病率存在性别差异，且与女性的相关性更强，因此进行了这项研究，以测试睡眠不足对导致促炎细胞因子活性的细胞机制的影响。在 26 名健康成年人（11 名女性；15 名男性）中，在基线期和部分睡眠剥夺后（从 23:00 到 3:00 清醒），分别于 08:00、12:00、16:00、20:00 和 23:00 评估单核细胞内促炎细胞因子的产生。在一夜睡眠不足后的早晨，单核细胞产生的白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）在两性之间表现出不同的变化。虽然女性和男性在 PSD 后立即的早晨均表现出 LPS 刺激的 IL-6 和 TNF-α产生显著增加，但与男性相比，女性在傍晚和深夜的这些细胞因子的产生增加。睡眠不足会引起单核细胞促炎细胞因子反应的功能改变，与男性相比，女性表现出更大的细胞免疫激活。这些结果对于理解睡眠障碍在性别之间炎症性疾病的不同风险特征中的作用具有重要意义。
