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本文引用的文献

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The many faces of semaphorins: from development to pathology.信号素的多面性：从发育到病理学
Cell Mol Life Sci. 2009 Feb;66(4):649-66. doi: 10.1007/s00018-008-8518-z.
2
Semaphorins and their receptors in lung cancer.肺癌中的信号素及其受体
Cancer Lett. 2009 Jan 8;273(1):1-14. doi: 10.1016/j.canlet.2008.05.032. Epub 2008 Jul 14.
3
The semaphorins: versatile regulators of tumour progression and tumour angiogenesis.信号素：肿瘤进展和肿瘤血管生成的多功能调节因子
Nat Rev Cancer. 2008 Aug;8(8):632-45. doi: 10.1038/nrc2404. Epub 2008 Jun 26.
4
Semaphorins in vascular development and head and neck squamous cell carcinoma-induced angiogenesis.血管生成以及头颈部鳞状细胞癌诱导血管生成过程中的信号素
Oral Oncol. 2008 Jun;44(6):523-31. doi: 10.1016/j.oraloncology.2007.10.005. Epub 2008 Jan 18.
5
The semaphorins.信号素
Genome Biol. 2006;7(3):211. doi: 10.1186/gb-2006-7-3-211. Epub 2006 Mar 30.
6
Semaphorins command cells to move.信号素指挥细胞移动。
Nat Rev Mol Cell Biol. 2005 Oct;6(10):789-800. doi: 10.1038/nrm1740.
7
Plexins: axon guidance and signal transduction.丛状蛋白：轴突导向与信号转导
Cell Mol Life Sci. 2005 Jun;62(12):1363-71. doi: 10.1007/s00018-005-5018-2.
8
Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans.信号素5A是一种由硫酸乙酰肝素和硫酸软骨素蛋白聚糖调节的双功能轴突导向因子。
Neuron. 2004 Dec 16;44(6):961-75. doi: 10.1016/j.neuron.2004.12.002.
9
The sema domain.信号素结构域。
Curr Opin Struct Biol. 2004 Dec;14(6):669-78. doi: 10.1016/j.sbi.2004.10.010.
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Semaphorins in cancer.癌症中的信号素
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信号素5A及其受体丛状蛋白B3的表达促进胃癌的侵袭和转移。

Expression of semaphorin 5A and its receptor plexin B3 contributes to invasion and metastasis of gastric carcinoma.

作者信息

Pan Guo-Qing, Ren Hong-Zheng, Zhang Shu-Fang, Wang Xi-Mei, Wen Ji-Fang

机构信息

Department of Pathology, Xiangya Medical College, Central South University, Changsha, Hunan Province, China.

出版信息

World J Gastroenterol. 2009 Jun 14;15(22):2800-4. doi: 10.3748/wjg.15.2800.

DOI:10.3748/wjg.15.2800
PMID:19522033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2695898/
Abstract

AIM

To investigate the protein and mRNA expression of semaphorin 5A and its receptor plexin B3 in gastric carcinoma and explore its role in the invasion and metastasis of gastric carcinoma.

METHODS

Expression of semaphorin 5A and its receptor plexin B3 in 48 samples of primary gastric carcinoma, its corresponding non-neoplastic mucosa, and matched regional lymph node metastasis was assayed by reverse transcription-polymerase chain reaction (RT-PCR), real-time RT-PCR and Western blotting.

RESULTS

The protein and mRNA expression of semaphorin 5A and its receptor plexin B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma and lymph node metastasis (P < 0.05). Moreover, the expression of semaphorin 5A was closely correlated with that of plexin B3.

CONCLUSION

Semaphorin 5A and its receptor plexin B3 play an important role in the invasion and metastasis of gastric carcinoma.

摘要

目的

研究信号素5A及其受体丛状蛋白B3在胃癌中的蛋白和mRNA表达，并探讨其在胃癌侵袭和转移中的作用。

方法

采用逆转录-聚合酶链反应（RT-PCR）、实时RT-PCR和蛋白质印迹法检测48例原发性胃癌样本及其相应的非肿瘤性黏膜组织以及配对的区域淋巴结转移灶中信号素5A及其受体丛状蛋白B3的表达。

结果

信号素5A及其受体丛状蛋白B3的蛋白和mRNA表达在非肿瘤性黏膜、原发性胃癌及淋巴结转移灶中逐渐升高（P<0.05）。此外，信号素5A的表达与丛状蛋白B3的表达密切相关。

结论

信号素5A及其受体丛状蛋白B3在胃癌的侵袭和转移中起重要作用。