Chiu Susan S, Chan Kwok-Hung, Tu Wenwei, Lau Yu Lung, Peiris J S Malik
Department of Pediatric and Adolescent Medicine, The University of Hong Kong, Hong Kong, China.
Vaccine. 2009 Jul 30;27(35):4834-9. doi: 10.1016/j.vaccine.2009.05.066. Epub 2009 Jun 11.
We aimed to explore intradermal influenza vaccination in infants <6 months. One hundred twenty-six infants 2-3 months of age were randomized to receive either two doses, 1 month apart, of 0.25 ml of a trivalent inactivated influenza vaccine (7.5 microg of hemagglutinin per strain) via the intramuscular (IM) route or 0.1 ml of the same vaccine (3 microg of hemagglutinin per strain) via the intradermal (ID) route. The vaccine was well tolerated. Only four infants had hemagglutination inhibition (HAI) titer <40 against > or =1 vaccine-covered antigen pre-vaccination. There was no difference in fold-rise of HAI titer response between those in the IM or ID group. We documented maintenance of HAI titers above seroprotective levels against all three vaccine antigens in 97.6% of subjects regardless of vaccination methods over a time of waning maternal antibodies.
我们旨在探索6个月以下婴儿的皮内流感疫苗接种情况。126名2至3个月大的婴儿被随机分为两组，一组通过肌肉注射（IM）途径，间隔1个月接种两剂0.25毫升三价灭活流感疫苗（每株含7.5微克血凝素）；另一组通过皮内（ID）途径接种0.1毫升相同疫苗（每株含3微克血凝素）。疫苗耐受性良好。仅4名婴儿在接种疫苗前针对≥1种疫苗覆盖抗原的血凝抑制（HAI）效价<40。IM组和ID组之间HAI效价反应的升高倍数没有差异。我们记录到，在母体抗体逐渐减少的一段时间内，无论接种方法如何，97.6%的受试者针对所有三种疫苗抗原的HAI效价均维持在血清保护水平以上。
